Wild-type mice weight following 6-thio-dG and 6-thioguanine treatment. Wild-type mice weight following 6-thio-dG and 6-thioguanine treatment. A, 5 mg/kg of 6-thio-dG (compared with DMSO/PBS or 5 mg/kg of 6-thioguanine). B, 1.67 mg/kg of 6-thio-dG (compared with DMSO/PBS or 1.67 mg/kg of 6-thioguanine) was injected i.p. into the 129S female wild-type mice for 25 days. The mice weight (g) was scaled every day (n = 3). Ilgen Mender et al. Cancer Discovery 2015;5:82-95 ©2015 by American Association for Cancer Research