Immunopathology of atopic dermatitis

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Presentation transcript:

Immunopathology of atopic dermatitis Pierre-Olivier Fiset, BSc, Donald Y.M. Leung, MD, PhD, Qutayba Hamid, MD, PhD Journal of Allergy and Clinical Immunology Volume 118, Issue 1, Pages 287-290 (July 2006) DOI: 10.1016/j.jaci.2006.03.046 Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Hematoxylin and eosin stain of skin lesions in patients with AD. Note the large numbers of small mononuclear cells infiltrating the tissue. Journal of Allergy and Clinical Immunology 2006 118, 287-290DOI: (10.1016/j.jaci.2006.03.046) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Immunohistochemistry demonstrates large numbers of infiltrating CD4+ cells stained with fast red by using the alkaline phosphatase method in skin lesions of patients with acute AD. Journal of Allergy and Clinical Immunology 2006 118, 287-290DOI: (10.1016/j.jaci.2006.03.046) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Radio in situ hybridization, as visualized by means of darkfield illumination, of IL-4 mRNA+ cells (A) and IFN-γ mRNA+ cells (B). Arrows point to representative cells positive for accumulation of the IL-4 probe. Journal of Allergy and Clinical Immunology 2006 118, 287-290DOI: (10.1016/j.jaci.2006.03.046) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 Radio in situ hybridization, as visualized by means of darkfield illumination, of GM-CSF mRNA+ cells. Journal of Allergy and Clinical Immunology 2006 118, 287-290DOI: (10.1016/j.jaci.2006.03.046) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 5 A, In situ hybridization with digoxigenin-labeled antisense probe of eotaxin mRNA+ cells stained in red in the epidermal layer of the skin obtained from subjects with chronic AD. Note the presence of some positive cells within the subepithelial layer (arrow). B, Negative control from subjects with chronic AD with use of digoxigenin-labeled sense probe. Journal of Allergy and Clinical Immunology 2006 118, 287-290DOI: (10.1016/j.jaci.2006.03.046) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 6 Mirror sections of lesions from active AD. A, Lesions were stained for IL-16 protein–positive cells by means of the indirect immunoperoxidase method. B, Lesions were stained for CD1a by using the alkaline phosphatase–antialkaline phosphatase method. Solid arrowheads and open arrowheads indicate CD1a+ cells also positive for IL-16 and negative for IL-16, respectively. Journal of Allergy and Clinical Immunology 2006 118, 287-290DOI: (10.1016/j.jaci.2006.03.046) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 7 Representative examples of total collagen deposition, as detected by using van Gieson staining in skin from patients with chronic (A) and acute (B) AD. Journal of Allergy and Clinical Immunology 2006 118, 287-290DOI: (10.1016/j.jaci.2006.03.046) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 8 Immunohistochemistry, by means of the indirect immunoperoxidase method, was used to detect human β-defensin 3 in psoriasis skin lesions (A) and in AD skin lesions (B). Journal of Allergy and Clinical Immunology 2006 118, 287-290DOI: (10.1016/j.jaci.2006.03.046) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions