Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites Randy M Stevens, MD, M.Salik Jahania, MD, Jennifer E.

Slides:

Advertisements

Similar presentations

Reduction of systolic and diastolic dysfunction by retrograde coronary sinus perfusion during off-pump coronary surgery Manuel Castellá, MD, Gerald D.

Advertisements

Recurrent Angina Caused by Coronary Subclavian Steal Syndrome Confirmed by Positron Emission Tomography Paulo Cury Rezende, MD, Leandro Menezes Alves.

B. Zane Atkins, MD, Scott C. Silvestry, MD, Ravi N. Samy, MD, Ashish S

Hypercholesterolemia Impairs the Myocardial Angiogenic Response in a Swine Model of Chronic Ischemia: Role of Endostatin and Oxidative Stress Munir Boodhwani,

Recombinant human complement C5a receptor antagonist reduces infarct size after surgical revascularization Robert D. Riley, MD, Hiroki Sato, MD, PhD,

Adenosine-enhanced ischemic preconditioning modulates necrosis and apoptosis: effects of stunning and ischemia–reperfusion Bradford Stadler, BS, Jonathan.

Myocardial protection with intermittent cold blood during aortic valve operation: antegrade versus retrograde delivery Attilio A Lotto, FRCS, Raimondo.

Salah Sabbagh, MD, Michele M. Henry Salzman, BS, Robert A

Single-Trunk Anomalous Origin of Both Coronary Arteries From Pulmonary Artery: Serendipitous Diagnosis and Successful Surgical Treatment Changwei Zhang,

Anomalous aortic origin of a coronary artery in the Ross operation: Attention to minor details averts major problems Igor E. Konstantinov, MD, PhD, FRACS

Nitric oxide–generating β-adrenergic blocker nipradilol preserves postischemic cardiac function Hitoshi Horimoto, MD, Adam E Saltman, MD, PhD, Glenn.

Hyperdynamic circulation of arteriovenous fistula preconditions the heart and limits infarct size Mahmoud A Mahgoub, MD, Jian-Hau Guo, MD, Shi-Ping Gao,

Ventricular septal rupture caused by myocardial bridging

Evidence of Nitric Oxide Produced by the Internal Mammary Artery Graft in Venous Drainage of the Recipient Coronary Artery Ferenc I. Tarr, MD, PhD, Mária.

Improved Myocardial Perfusion and Thickening After Off-Pump Revascularization: 5- Year Follow-Up Chang Young Kim, MD, Ho Young Hwang, MD, Jin Chul Paeng,

Michael D. Fridman, MD, Carl Y. Owada, MD, FACC, Richard D

Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J

Comparative Effects of Continuous Warm Blood and Intermittent Cold Blood Cardioplegia on Coronary Reactivity Motohisa Tofukuji, MD, PhD, Alon Stamler,

Richard Gitter, Chris M. Cate, Kenneth Smart, G.Kimble Jett

Progressive improvement of myocardial perfusion after off-pump revascularization with bilateral internal thoracic arteries: Comparison of early versus.

Blood cardioplegia enhanced with nitric oxide donor SPM-5185 counteracts postischemic endothelial and ventricular dysfunction Katsuhiko Nakanishi, MD,

Basal nitric oxide expresses endogenous cardioprotection during reperfusion by inhibition of neutrophil-mediated damage after surgical revascularization

Focal angiogen therapy using intramyocardial delivery of an adenovirus vector coding for vascular endothelial growth factor 1211 Leonard Y Lee, MD, Shailen.

Hiroki Sato, James E Jordan, Zhi-Qing Zhao, S

Proteasome Inhibition Attenuates Infarct Size and Preserves Cardiac Function in a Murine Model of Myocardial Ischemia-Reperfusion Injury William E. Stansfield,

Snaring of the Target Vessel in Less Invasive Bypass Operations Does Not Cause Endothelial Dysfunction Louis P Perrault, Philippe Menasché, Jean-Pierre.

Endogenous myocardial angiogenesis and revascularization using a gastric submucosal patch Marc A Ruel, MD, MPh, Frank W Sellke, MD, Cesario Bianchi,

Long-term treatment with nipradilol, a nitric oxide–releasing β-adrenergic blocker, enhances postischemic recovery and limits infarct size Yoshihiro.

Aortic root replacement with anomalous origin of the coronary arteries

Opioid preconditioning: myocardial function and energy metabolism

Myocardial revascularization with the posterior tibial artery

Potent adenylate cyclase agonist forskolin restores myoprotective effects of ischemic preconditioning in rat hearts after myocardial infarction Shigetoshi.

LV-powered coronary sinus retroperfusion reduces infarct size in acutely ischemic pigs Jeffrey S Martin, MD, John G Byrne, MD, Olivier Y Ghez, MD, Umer.

Transmyocardial laser as an adjunct to minimally invasive CABG for complete myocardial revascularization Naresh Trehan, MD, Yugal Mishra, PhD, Yatin.

J. Trent Magruder, MD, Todd C

Role of myocardial temperature measurement in monitoring the adequacy of myocardial protection during cardiac surgery Joseph A Dearani, MD, Trevor C.

Coronary Artery Fistulae Involving Both Right and Left Coronary Arteries Ahmet Bolukcu, MD, Ahmet Can Topcu, MD, Yavuz Sensoz, MD, Ilyas Kayacioglu, MD

Transposition of the great arteries with anomalous origin of the left coronary artery from the pulmonary artery Masaaki Yamagishi, MD, Takeshi Emmoto,

Complete Revascularization of the Three-Vessel Territories Using a Left Internal Thoracic Artery Composite Graft Ho Young Hwang, MD, PhD, Hong Chul Oh,

Single coronary artery and complete transposition of the great arteries: a technical challenge resolved? Vinayak Shukla, Robert M Freedom, MD, Michael.

Munir Boodhwani, MD, William E

Experimental study of intermittent crossclamping with fibrillation and myocardial protection: Reduced injury from shorter cumulative ischemia or intrinsic.

Efficacy of Therapeutic Angiogenesis by Intramyocardial Injection of pCK-VEGF165 in Pigs Jae-Sung Choi, MD, PhD, Ki-Bong Kim, MD, PhD, Woong Han, DVM,

Ischemic preconditioning does not improve myocardial preservation during off-pump multivessel coronary operation Hannu J Penttilä, MD, Martti V.K Lepojärvi,

Ischemic preconditioning does not acutely improve load-insensitive parameters of contractility in in vivo stunned porcine myocardium M.Salik Jahania,

Ventriculocoronary artery bypass results using a mesh-tipped device in a porcine model Robert W Emery, MD, Frazier Eales, MD, Clifford H Van Meter, MD,

Protein kinase C isoform–dependent myocardial protection by ischemic preconditioning and potassium cardioplegia Kejie Lu, MD*, Hajime Otani, MD, Tadashi.

Near-infrared monitoring of myocardial oxygenation during ischemic preconditioning Michio Kawasuji, MD, Masahiro Ikeda, MD, Naoki Sakakibara, MD, Susumu.

Optimal dose and mode of delivery of Na+/H+ exchange-1 inhibitor are critical for reducing postsurgical ischemia-reperfusion injury Joel S Corvera, MD,

Comparison of developmental endothelial locus-1 angiogenic factor with vascular endothelial growth factor in a porcine model of cardiac ischemia Murray.

M.Keith Odayan, Hugh S Paterson The Annals of Thoracic Surgery

Transmyocardial laser revascularization: experimental studies in healthy porcine myocardium Georg Lutter, MD, Juergen Martin, MD, Noriyuki Takahashi,

Raymond Cartier, MD, Robert Blain, MD The Annals of Thoracic Surgery

Role of Nitric Oxide Pathway in Placental Dysfunction Following Fetal Bypass Christopher Lam, BS, R. Scott Baker, BS, Jerri McNamara, CCP, Robert Ferguson,

Adenosine-enhanced ischemic preconditioning provides myocardial protection equal to that of cold blood cardioplegia James D McCully, PhD, Masahisa Uematsu,

Myocardial stunning: A therapeutic conundrum

Development of a Minimally Invasive Technique for Coronary Revascularization in a Porcine Model M.Clive Robinson, David R Gross, Kenneth A Thielmeier,

Postischemic Function and Protein Kinase C Signal Transduction

Staged Therapeutic Approach in Spontaneous Coronary Dissection

Adam E Saltman, MD, PhD, Walter H Dzik, MD, Sidney Levitsky, MD

Minimally invasive direct coronary artery bypass in a cardiac transplant recipient with allograft vasculopathy Ivan Aleksic, MD, PhD, Jarowit A Piotrowski,

Henry F Tripp, MD, Robert M Stiegel, MD, Joseph P Coyle, MD

Sérgio A de Oliveira, MD The Annals of Thoracic Surgery

Robert R Lazzara, MD, Francis E Kidwell, BS

Catheter-Based Endoscopic Bypass Grafting: An Experimental Feasibility Study Stephan Jacobs, MD, David Holzhey, MD, Hubert Stein, BS, BME, Friedrich W.

Anomalous right coronary artery from the pulmonary artery in Taussig-Bing anomaly Benjamin W Eidem, MD, Frank Cetta, MD, Patrick T Roughneen, Serafin.

Randy M. Stevens, MD, M. Salik Jahania, MD, Robert M

Renato Faro, PhD, Yoshiya Toyoda, MD, James D

OPCAB for Acute LAD Dissection Due to Blunt Chest Trauma

Intraoperative Coronary Artery Dissection in Fibromuscular Dysplasia

Presentation transcript:

Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites Randy M Stevens, MD, M.Salik Jahania, MD, Jennifer E Stivers, BS, Robert M Mentzer, MD, Robert D Lasley, PhD The Annals of Thoracic Surgery Volume 73, Issue 4, Pages 1261-1266 (April 2002) DOI: 10.1016/S0003-4975(02)03372-6

Fig 1 Dialysate nitric oxide (NO) metabolite concentration (NOx) in the left anterior descending (LAD) artery and left circumflex (LCX) coronary artery beds during 15 minutes of LAD occlusion (ISCH) and 2 hours reperfusion. Values are expressed as percent change from preischemic (PreISCH) baseline. ∗p < 0.05 versus baseline. The Annals of Thoracic Surgery 2002 73, 1261-1266DOI: (10.1016/S0003-4975(02)03372-6)

Fig 2 Dialysate nitric oxide (NO) metabolite concentrations (NOx) in the midmyocardium during 60 minutes of ischemia and 2 hours reperfusion. Values are expressed as percent change from baseline (time 0). Dialysate left circumflex (LCX) coronary artery values during left anterior descending (LAD) artery occlusion were not significantly different from baseline. ∗p < 0.05 versus baseline. (PreISCH = preischemic.) The Annals of Thoracic Surgery 2002 73, 1261-1266DOI: (10.1016/S0003-4975(02)03372-6)

Fig 3 The effects of ischemic preconditioning on dialysate (NOx). Preconditioning was induced by two cycles of 5 minutes of ischemia ([ISCH] gray bars) and 10 minutes of reperfusion ([RP] black bars). Values are expressed as percent change from preischemic (PreISCH) baseline. ∗p < 0.05 versus baseline. The Annals of Thoracic Surgery 2002 73, 1261-1266DOI: (10.1016/S0003-4975(02)03372-6)

Fig 4 Dialysate (NOx) during (A) prolonged ischemia and (B) ischemia and reperfusion in 60-minute ischemia alone (60′ Isch alone) and ischemic preconditioned (IPC) pigs. All ischemic NOx values (A) were significantly different from respective preischemic (PreISCH) baseline values (p < 0.05) but symbols were not shown for clarity. ∗p < 0.05 versus control group value; #p < 0.05 versus respective PreISCH value. (LAD = left anterior descending artery.) The Annals of Thoracic Surgery 2002 73, 1261-1266DOI: (10.1016/S0003-4975(02)03372-6)