Biological Functions of Activity-Dependent Transcription Revealed

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Biological Functions of Activity-Dependent Transcription Revealed Anne E. West Neuron Volume 60, Issue 4, Pages 523-525 (November 2008) DOI: 10.1016/j.neuron.2008.11.008 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Schematic for the Role of Activity-Dependent Bdnf Transcription in the Regulation of GABAergic Synapses (1) Excitatory synaptic activity (Glu) leads to the activation of intracellular calcium signaling cascades. (2) In the nucleus, calcium-activated kinases phosphorylate CREB and modulate additional transcriptional regulators bound to three calcium-response elements (CaREs) in the proximal region of Bdnf promoter IV. (3) Transcription of Bdnf exon IV is initiated, and newly synthesized BDNF protein is translated and packaged for secretion. (4) Secreted BDNF increases the number of GABAergic synapses. Neuron 2008 60, 523-525DOI: (10.1016/j.neuron.2008.11.008) Copyright © 2008 Elsevier Inc. Terms and Conditions