Metastatic signals respond to castration.

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Metastatic signals respond to castration. Metastatic signals respond to castration. A, live imaging time course of two castrated RapidCaP mice (LV-Cre/Luci–injected PtenloxP/loxP;Trp53loxP/loxP mouse). Surgical castration was performed 5 months after injection on mice harboring distant secondary disease (see Castr.). Imaging analysis reveals differential response and recurrence of disease after castration. B, three-dimensional plot of signal intensity time course from A, including control mice: 1, wt untreated mouse; 2, RapidCaP mouse; 3, mock-castrated RapidCaP mouse; 4 and 5, castrated RapidCaP mice. C, quantification of luminescence signals in castrated animals reveals a sharp increase in the rate of disease progression after relapse. “C” denotes castration. D, close-up analysis of graphs from C shows that both primary and secondary disease respond to castration, confirming their hormone dependence. Hyejin Cho et al. Cancer Discovery 2014;4:318-333 ©2014 by American Association for Cancer Research