Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs

Slides:

Advertisements

Similar presentations

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

Advertisements

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Distinct Self-Renewal and Differentiation Phases in the Niche of Infrequently Dividing Hair Follicle Stem Cells Ying V. Zhang, Janice Cheong, Nichita Ciapurin,

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair Francesco S. Loffredo, Matthew L. Steinhauser,

Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells David J. Wong, Helen Liu, Todd W. Ridky, David Cassarino, Eran Segal, Howard.

Wnt1-lmx1a Forms a Novel Autoregulatory Loop and Controls Midbrain Dopaminergic Differentiation Synergistically with the SHH-FoxA2 Pathway Sangmi Chung,

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle Isabel Beerman, Jun Seita, Matthew A.

Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells Keriayn N. Smith, Amar M. Singh, Stephen Dalton Cell Stem Cell Volume 7, Issue.

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities Koen Schepers, Timothy B. Campbell, Emmanuelle Passegué Cell Stem Cell Volume.

Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.

Kevin G. Chen, Barbara S. Mallon, Ronald D.G. McKay, Pamela G. Robey

Cutaneous Cancer Stem Cells: β-Catenin Strikes Again

Volume 13, Issue 2, Pages (August 2013)

Stress Can Be a Good Thing for Blood Formation

Cancer: Inappropriate Expression of Stem Cell Programs?

Kevin G. Chen, Barbara S. Mallon, Ronald D.G. McKay, Pamela G. Robey

Scott N. Freeman, Kathryn A. Burke, Menfo A. Imoisili, Timothy R. Coté

FoxO: A New Addition to the ESC Cartel

Volume 1, Issue 1, Pages (June 2007)

Cell Cycle Rules Pluripotency

Adipocytes at the Core of Bone Function

Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

A Path to Insulin Independence: “The End of the Beginning”

Volume 9, Issue 2, Pages (August 2011)

Volume 16, Issue 6, Pages (June 2015)

Gerry P. Crossan, Juan I. Garaycoechea, Ketan J. Patel Cell Stem Cell

Blocking HIF1α Activity Eliminates Hematological Cancer Stem Cells

Volume 2, Issue 6, Pages (June 2008)

Anselme Perrier, Marc Peschanski Cell Stem Cell

Natalia J. Martinez, Richard I. Gregory Cell Stem Cell

Transplantable Liver Organoids Made from Only Three Ingredients

Regulating Cancer Stem Cells the miR Way

Haunting the HOXA Locus: Two Faces of lncRNA Regulation

Wing Y. Chang, William L. Stanford Cell Stem Cell

Human Somatic Cell Nuclear Transfer Is Alive and Well

Stem Cell Therapies in Clinical Trials: Progress and Challenges

Stem Cell Aging and Sex: Are We Missing Something?

Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

Cutaneous Cancer Stem Cells: β-Catenin Strikes Again

MicroRNA Regulation of Stem Cell Fate

CHD7 in Charge of Neurogenesis

Tim Willinger, Richard A. Flavell Cell Stem Cell

Blocking HIF1α Activity Eliminates Hematological Cancer Stem Cells

Putting Two Heads Together to Build a Better Brain

Arven Saunders, Jianlong Wang Cell Stem Cell

Puma: Mauling the Intestinal Crypt

Pluripotent Stem Cells and Disease Modeling

Transplantable Liver Organoids Made from Only Three Ingredients

Giulia Caglio, Elena Torlai Triglia, Ana Pombo Cell Stem Cell

Enhanc(er)ing Skin Stem Cells

Meddling with METTLs in Normal and Leukemia Stem Cells

Volume 21, Issue 1, Pages (July 2017)

Regulating Autologous Adult Stem Cells: The FDA Steps Up

Timothy R. Donahue, David W. Dawson Cell Stem Cell

Policy Uncertainty and the Conduct of Stem Cell Research

Selfish Stem Cells Compete with Each Other

Volume 22, Issue 4, Pages (April 2018)

Regulating Autologous Adult Stem Cells: The FDA Steps Up

Chapter 29 - Stem Cells and Generation of New Cells in the

Mesp1 at the Heart of Mesoderm Lineage Specification

Jeremy Sugarman, Andrew Siegel Cell Stem Cell

Devyn M. Smith, Emily J. Culme-Seymour, Chris Mason Cell Stem Cell

Presentation transcript:

Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs Ozren Bogdanović, Ryan Lister Cell Stem Cell Volume 16, Issue 5, Pages 459-460 (May 2015) DOI: 10.1016/j.stem.2015.04.009 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Differentiation Potential of hESC DNMT Mutant Lines DNMT1 is essential for hESC viability, and disruption of DNMT1 in hESCs causes immediate cell death. Both DNMT3A and DNMT3B are dispensable for hESC maintenance and differentiation as exemplified by embryoid body (EB) and teratoma formation in DNMT3A−/−, DNMT3B−/−, and DNMT3A−/−; DNMT3B−/− mutant lines. Cell Stem Cell 2015 16, 459-460DOI: (10.1016/j.stem.2015.04.009) Copyright © 2015 Elsevier Inc. Terms and Conditions