Beneficial effect of autologous cell transplantation on infarcted heart function: comparison between bone marrow stromal cells and heart cells  Terrence.

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Beneficial effect of autologous cell transplantation on infarcted heart function: comparison between bone marrow stromal cells and heart cells  Terrence M Yau, MD, MS, Shinji Tomita, MD, Richard D Weisel, MD, Zhi-Qiang Jia, MD, Laura C Tumiati, MS, Donald A.G Mickle, MD, Ren-Ke Li, MD, PhD  The Annals of Thoracic Surgery  Volume 75, Issue 1, Pages 169-177 (January 2003) DOI: 10.1016/S0003-4975(02)04290-X

Fig 1 Photomicrographs of cultured (A) bone marrow cells and (B) heart cells before transplantation. (×200 before 44% reduction.) The Annals of Thoracic Surgery 2003 75, 169-177DOI: (10.1016/S0003-4975(02)04290-X)

Fig 2 A representative polar map of left ventricular perfusion, generated by 99mTc-sestamibi single-photon emission tomography (99mTc-MIBI SPECT), (a) before and (b) 4 weeks after bone marrow cell transplantation. (c) Changes in infarct zone perfusion scores, evaluated by 99mTc-MIBI SPECT, in the bone marrow cell (BMC) transplanted, heart cell (HC) transplanted, and control pigs. Perfusion scores decreased over the 4-week period after transplantation in the control animals, but increased to a similar extent in both the cell transplanted groups (p = 0.033). (Tx = transplantation.) The Annals of Thoracic Surgery 2003 75, 169-177DOI: (10.1016/S0003-4975(02)04290-X)

Fig 3 (A) Preload-recruitable stroke work (PRSW, the slope of the stroke work–end-diastolic volume relation) 4 weeks after transplantation of bone marrow cells, heart cells, or culture medium alone (controls). A significant interactive effect of group × end-diastolic volume on stroke work was noted (p < 0.001). PRSW was greatest in the heart cell-transplanted pigs. (B) The end-systolic pressure–volume relation. Transplantation of bone marrow cells or heart cells shifted the end-systolic pressure–volume relation to the left (p < 0.001). (BMC = bone marrow cells; CN = control; HC = heart cells; SW = stroke work.) The Annals of Thoracic Surgery 2003 75, 169-177DOI: (10.1016/S0003-4975(02)04290-X)

Fig 4 Photomicrographs of representative sections of a pig heart transplanted with bone marrow cells (A–C) or heart cells (D–F). Sections were stained with hematoxylin & eosin (A, D), antibodies against bromodeoxyuridine (BrdU) (B, E), or antibodies against troponin I (C, F). Both bone marrow cells and heart cells engrafted within the infarct zone. BrdU-positive cells in the bone marrow cell-transplanted hearts and the heart cell-transplanted hearts are indicated by arrows (B, E). In both the bone marrow cell- and heart cell-transplanted hearts, troponin I-positive cells were also noted in the infarct zone. Arrows indicate blood vessels in the transplanted scar (A, F). (×200 before 20% reduction.) The Annals of Thoracic Surgery 2003 75, 169-177DOI: (10.1016/S0003-4975(02)04290-X)