Beneficial effect of autologous cell transplantation on infarcted heart function: comparison between bone marrow stromal cells and heart cells Terrence.

Slides:

Advertisements

Similar presentations

The coronary delivery of marrow stromal cells for myocardial regeneration: Pathophysiologic and therapeutic implications Jih-Shiuan Wang, MD, Dominique.

Advertisements

Elastin Stabilizes an Infarct and Preserves Ventricular Function by Tomohiro Mizuno, Terrence M. Yau, Richard D. Weisel, Chris G. Kiani, and Ren- Ke Li.

Human Cord Blood Stem Cells Enhance Neonatal Right Ventricular Function in an Ovine Model of Right Ventricular Training Ben Davies, MRCS(Eng), PhD, Ngaire.

Paracrine Action Enhances the Effects of Autologous Mesenchymal Stem Cell Transplantation on Vascular Regeneration in Rat Model of Myocardial Infarction

Cell transplantation to prevent heart failure: a comparison of cell types Takeshiro Fujii, MD, Terrence M Yau, MD, MS, Richard D Weisel, MD, Nobuhisa.

Uswa Shahzad, BHSc, Guangming Li, MD, Yaoguang Zhang, MD, Terrence M

Tracking cardiac engraftment and distribution of implanted bone marrow cells: Comparing intra-aortic, intravenous, and intramyocardial delivery Shu-Hong.

Tracking cardiac engraftment and distribution of implanted bone marrow cells: Comparing intra-aortic, intravenous, and intramyocardial delivery Shu-Hong.

Therapeutic Effect of Midkine on Cardiac Remodeling in Infarcted Rat Hearts Shinya Fukui, MD, Satoru Kitagawa-Sakakida, MD, PhD, Sin Kawamata, MD, PhD,

Therapeutic angiogenesis using autologous bone marrow stromal cells: improved blood flow in a chronic limb ischemia model Abdulaziz Al-Khaldi, MD, Hilal.

Cardiomyocyte transplantation does not reverse cardiac remodeling in rats with chronic myocardial infarction Yutaka Sakakibara, MD, Keiichi Tambara,

Repair of Myocardial Infarction by Epicardial Deposition of Bone Marrow Cell-Coated Muscle Patch in a Murine Model Laurent Barandon, MD, Thierry Couffinhal,

Cardiomyocyte Transplantation Improves Heart Function

Optimal time for cardiomyocyte transplantation to maximize myocardial function after left ventricular injury Ren-Ke Li, MD, PhD, Donald A.G. Mickle,

Cell transplantation to prevent heart failure: a comparison of cell types Takeshiro Fujii, MD, Terrence M Yau, MD, MS, Richard D Weisel, MD, Nobuhisa.

Left Ventricular Bronchogenic Cyst

Cell-based gene therapy modifies matrix remodeling after a myocardial infarction in tissue inhibitor of matrix metalloproteinase-3–deficient mice Denis.

Paracrine Action Enhances the Effects of Autologous Mesenchymal Stem Cell Transplantation on Vascular Regeneration in Rat Model of Myocardial Infarction

An ovine model of postinfarction dilated cardiomyopathy

Right ventricular dysfunction after cardiac transplantation: primarily related to status of donor heart Hartmuth B Bittner, MD, PhD, Edward P Chen, MD,

Quantitative analysis of survival of transplanted smooth muscle cells with real-time polymerase chain reaction Tamotsu Yasuda, MD, PhD, Richard D. Weisel,

Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects Jay G. Shake, MD, Peter J. Gruber, MD, PhD,

Cell transplantation preserves cardiac function after infarction by infarct stabilization: Augmentation by stem cell factor Shafie Fazel, MD, MSc, Liwen.

Cardiac cell transplantation: closer to bedside

Potassium-channel opener cardioplegia is superior to St

Malignant B-Cell Lymphoma Arising in a Large, Left Atrial Myxoma

Ventricular septal rupture caused by myocardial bridging

Biodegradable vs Nonbiodegradable Cardiac Support Device for Treating Ischemic Cardiomyopathy in a Canine Heart Mutsunori Kitahara, MD, Shigeru Miyagawa,

CTSNet: a unique educational vehicle

Abdominal Aorta Aneurysms in Children: Single-Center Experience of Six Patients Caisheng Ye, MD, PhD, Henghui Yin, MD, PhD, Ying Lin, MD, PhD, Li Zhou,

Autologous smooth muscle cell transplantation improved heart function in dilated cardiomyopathy Kyung-Jong Yoo, MD, Ren-Ke Li, MD, PhD, Richard D. Weisel,

Tomohiro Mizuno, MD, Richard D. Weisel, MD, Ren-Ke Li, MD, PhD

Superiority of magnesium cardioplegia in neonatal myocardial protection Michael T Kronon, MD, Bradley S Allen, MD, Janeen Hernan, MS, Ari O Halldorsson,

Aging impairs the angiogenic response to ischemic injury and the activity of implanted cells: Combined consequences for cell therapy in older recipients

Targeted overexpression of leukemia inhibitory factor to preserve myocardium in a rat model of postinfarction heart failure Mark F. Berry, MD, Timothy.

Hyperglycemia exaggerates ischemia-reperfusion–induced cardiomyocyte injury: Reversal with endothelin antagonism Subodh Verma, MD, PhD, Andrew Maitland,

Human Cord Blood Stem Cells Enhance Neonatal Right Ventricular Function in an Ovine Model of Right Ventricular Training Ben Davies, MRCS(Eng), PhD, Ngaire.

Vascular endothelial growth factor transgene expression in cell-transplanted hearts Terrence M. Yau, MD, MSc, Guangming Li, MD, Richard D Weisel, MD,

Randomized Study of Mononuclear Bone Marrow Cell Transplantation in Patients With Coronary Surgery Qiang Zhao, MD, Yongxin Sun, MD, Limin Xia, MD, Anqing.

Donald J. Morris, MD, Andrew H. Fischer, MD, Jeffrey Abboud, MD

Alternation of left ventricular load by a continuous-flow left ventricular assist device with a native heart load control system in a chronic heart failure.

Marrow Stromal Cells as Universal Donor Cells for Myocardial Regenerative Therapy: Their Unique Immune Tolerance Rony Atoui, MD, MS, Juan-Francisco Asenjo,

Ji Zhang, MD, Robert D Furukawa, BSc, Stephen E Fremes, MD, Donald A

Percutaneous Tissue-Engineered Pulmonary Valved Stent Implantation

Daniel G. Nicastri, MD, Maoxin Wu, MD, PhD, Jaime Yun, MD, Scott J

Acute functional consequences of left ventriculotomy

The coronary delivery of marrow stromal cells for myocardial regeneration: Pathophysiologic and therapeutic implications Jih-Shiuan Wang, MD, Dominique.

Cyril Serrick, MSc, Adel Giaid, PhD, Alex Reis, MD, Hani Shennib, MD

Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation Shinji Tomita, MD, PhD, Donald.

Construction of a bioengineered cardiac graft

Pathology of the Radial and Internal Thoracic Arteries Used as Coronary Artery Bypass Grafts Eric Kaufer, BS, Stephen M Factor, MD, Rosemary Frame, MS,

Transplantation of cryopreserved cardiomyocytes

Nobuo Tsunooka, MD, PhD, Shin Hirayama, MD, PhD, Jeffrey A

Significant improvement of heart function by cotransplantation of human mesenchymal stem cells and fetal cardiomyocytes in postinfarcted pigs Jiang-Yong.

Tetsuro Sakai, MD, Ren-Ke Li, MD, MSc, PhD, Richard D

Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation Yutaka.

Shankha S Biswas, Edward P Chen, Hartmuth B Bittner, R

Vascular Leiomyoma of the Pulmonary Artery

Angiogenesis and growth factor expression in a model of transmyocardial revascularization Marc P. Pelletier, MD, Adel Giaid, PhD, Sujith Sivaraman, BSc,

Strategies of myocardial protection for operation in chronic model of cyanotic heart disease Ji Zhang, MD, W.R.Eric Jamieson, MD, Heidar Sadeghi, MD,

Xenotransplant cardiac chimera: immune tolerance of adult stem cells

Dynamic cardiomyoplasty: at the crossroads

Adenosine-enhanced ischemic preconditioning provides myocardial protection equal to that of cold blood cardioplegia James D McCully, PhD, Masahisa Uematsu,

Cardiovascular effects of induced hypothermia after lung transplantation Leif T. Eriksson, MD, Roger Roscher, MD, Richard Ingemansson, MD, PhD, Stig Steen,

Evan Loh, MD, Edward B. Lankford, MD, PhD, David J

Ren-Ke Li, MD, PhD, Richard D. Weisel, MD, Donald A. G

Vascular Endothelial Growth Factor Receptor Upregulation in Response to Cell-Based Angiogenic Gene Therapy Terrence M. Yau, MD, MS, Guangming Li, MD,

Transplantation of cryopreserved muscle cells in dilated cardiomyopathy: Effects on left ventricular geometry and function Nobuhisa Ohno, MD, Paul W.M.

Optimizing cardiac cell therapy: From processing to delivery

Glomus tumor of the trachea

Presentation transcript:

Beneficial effect of autologous cell transplantation on infarcted heart function: comparison between bone marrow stromal cells and heart cells Terrence M Yau, MD, MS, Shinji Tomita, MD, Richard D Weisel, MD, Zhi-Qiang Jia, MD, Laura C Tumiati, MS, Donald A.G Mickle, MD, Ren-Ke Li, MD, PhD The Annals of Thoracic Surgery Volume 75, Issue 1, Pages 169-177 (January 2003) DOI: 10.1016/S0003-4975(02)04290-X

Fig 1 Photomicrographs of cultured (A) bone marrow cells and (B) heart cells before transplantation. (×200 before 44% reduction.) The Annals of Thoracic Surgery 2003 75, 169-177DOI: (10.1016/S0003-4975(02)04290-X)

Fig 2 A representative polar map of left ventricular perfusion, generated by 99mTc-sestamibi single-photon emission tomography (99mTc-MIBI SPECT), (a) before and (b) 4 weeks after bone marrow cell transplantation. (c) Changes in infarct zone perfusion scores, evaluated by 99mTc-MIBI SPECT, in the bone marrow cell (BMC) transplanted, heart cell (HC) transplanted, and control pigs. Perfusion scores decreased over the 4-week period after transplantation in the control animals, but increased to a similar extent in both the cell transplanted groups (p = 0.033). (Tx = transplantation.) The Annals of Thoracic Surgery 2003 75, 169-177DOI: (10.1016/S0003-4975(02)04290-X)

Fig 3 (A) Preload-recruitable stroke work (PRSW, the slope of the stroke work–end-diastolic volume relation) 4 weeks after transplantation of bone marrow cells, heart cells, or culture medium alone (controls). A significant interactive effect of group × end-diastolic volume on stroke work was noted (p < 0.001). PRSW was greatest in the heart cell-transplanted pigs. (B) The end-systolic pressure–volume relation. Transplantation of bone marrow cells or heart cells shifted the end-systolic pressure–volume relation to the left (p < 0.001). (BMC = bone marrow cells; CN = control; HC = heart cells; SW = stroke work.) The Annals of Thoracic Surgery 2003 75, 169-177DOI: (10.1016/S0003-4975(02)04290-X)

Fig 4 Photomicrographs of representative sections of a pig heart transplanted with bone marrow cells (A–C) or heart cells (D–F). Sections were stained with hematoxylin & eosin (A, D), antibodies against bromodeoxyuridine (BrdU) (B, E), or antibodies against troponin I (C, F). Both bone marrow cells and heart cells engrafted within the infarct zone. BrdU-positive cells in the bone marrow cell-transplanted hearts and the heart cell-transplanted hearts are indicated by arrows (B, E). In both the bone marrow cell- and heart cell-transplanted hearts, troponin I-positive cells were also noted in the infarct zone. Arrows indicate blood vessels in the transplanted scar (A, F). (×200 before 20% reduction.) The Annals of Thoracic Surgery 2003 75, 169-177DOI: (10.1016/S0003-4975(02)04290-X)