Effect of silencing β-catenin on the invasion and metastasis of MHCC97 and Hep3B cells under normoxic and hypoxic conditions. Effect of silencing β-catenin.

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Effect of silencing β-catenin on the invasion and metastasis of MHCC97 and Hep3B cells under normoxic and hypoxic conditions. Effect of silencing β-catenin on the invasion and metastasis of MHCC97 and Hep3B cells under normoxic and hypoxic conditions. A, in vitro Transwell analysis revealed that depletion of β-catenin completely inhibited hypoxia-enhanced invasiveness of MHCC97 and Hep3B cells, and partially impaired their original invasiveness in normoxia. B, quantification of bioluminescence showed that HAL accelerated pulmonary metastasis in MHCC97-R xenografts and increased peritoneal seeding in Hep3B-R xenografts, compared with matched controls. However, the enhanced metastatic potential was abrogated significantly by silencing β-catenin. C, representative bioluminescence images visualized tumor metastatic loci in lung and peritoneum. Liang Liu et al. Clin Cancer Res 2010;16:2740-2750 ©2010 by American Association for Cancer Research