NIX loss delays cancer progression in KRAS-driven models of PDAC

Slides:

Advertisements

Similar presentations

Fig. 4. Representative microscopic images of core needle biopsy specimens. A. Paucicellular fibrotic nodule with calcification shows few atypical follicular.

Advertisements

Hes1 Controls Exocrine Cell Plasticity and Restricts Development of Pancreatic Ductal Adenocarcinoma in a Mouse Model Ana Hidalgo-Sastre, Roxanne L.

Reduced scar formation in the injured GM of CCR2−/− mice

Development of preclinical models for the guidance of precision medicine. Development of preclinical models for the guidance of precision medicine. A,

Jens T. Siveke, Roland M. Schmid Cancer Cell

Klotho reduction increases the expression of cytokine response factors in the CP. (A–C) ICAM1 (A and B) and IRF7 (C) immunoreactivity in the CP of 19-

Volume 141, Issue 3, Pages (September 2011)

Combined PLX3397 and PTX treatment inhibits metastasis in a CD8-dependent manner. Combined PLX3397 and PTX treatment inhibits metastasis in a CD8-dependent.

CD1dhiCD5+ B cells are expanded in pancreatic neoplasia and are functionally important for sustaining growth of KrasG12D-PDEC in vivo. CD1dhiCD5+ B cells.

Prmt7 deficiency causes a fiber-type switch toward glycolytic.

Renal microvascular injury 6 months after induction of JG cell-specific Gsα knockout. Renal microvascular injury 6 months after induction of JG cell-specific.

Atg7 deficiency has distinct consequences for tumor establishment and maintenance in BrafV600E-driven lung tumors and is associated with the emergence.

Volume 139, Issue 2, Pages e6 (August 2010)

Deficiency of Cdkn2a leads to aberrant activation of RhoA in vivo.

CCL21 localizes to T cell zone FRCs in young and aged spleens.

Expression of THBS2 in human PanIN tissue and PDAC tumor tissue

Fig. 5 EGFR mutation status of patients with NSCLC, detected by histological examination and ARMS PCR. EGFR mutation status of patients with NSCLC, detected.

Postnatal depletion of Drosha in the endothelium in mice results in HHT-like vascular abnormalities. Postnatal depletion of Drosha in the endothelium in.

Depletion of Drosha in the endothelium in mice results in embryonic developmental vascular abnormalities similar to HHT. Depletion of Drosha in the endothelium.

Molecular Therapy - Methods & Clinical Development

KRAS-induced chemoattractants mediate attraction of macrophages.

TANs mediate obesity-induced tumor progression and aggravated desmoplasia. TANs mediate obesity-induced tumor progression and aggravated desmoplasia. A,

Elysse C. Filipe et al. BTS 2018;3:38-53

Volume 22, Issue 3, Pages (September 2012)

Obesity aggravates tumor desmoplasia.

Indirect immunofluorescence analysis of σ in bladder specimens, in normal urothelium (A, cyst 981; B, cyst 981; C, cyst 1004; and D, cyst 975), and.

Pharmacologic inhibitors of PI3Kγ suppress PDAC growth and metastasis.

B cells infiltrate mouse and human pancreatic neoplasia and promote growth of KrasG12D-PDEC in vivo. B cells infiltrate mouse and human pancreatic neoplasia.

Dual‐recombinase fluorescence lineage tracing of EMT in KPF (FSF‐KrasG12D/+;Trp53frt/+;Pdx1‐Flp);αSMA‐Cre;R26Dual mice Dual‐recombinase fluorescence lineage.

NRP1-expressing myeloid cells influence adipocyte hypertrophy, development of fatty liver, and CLSs. NRP1-expressing myeloid cells influence adipocyte.

ILK knockdown decreases mTOR signaling in PKD kidneys.

NRP1-expressing myeloid cells contribute to adipose tissue vascularization. NRP1-expressing myeloid cells contribute to adipose tissue vascularization.

Inflammation is associated with increased basal-cell plasticity in the Nkx3.1 mutant prostate. Inflammation is associated with increased basal-cell plasticity.

Formation of papilloma lesions in the UroIICre+Fgfr3+/K644EK-RasG12D/+ model. Formation of papilloma lesions in theUroIICre+Fgfr3+/K644EK-RasG12D/+model.

Fgfr3 mutation is not the sole driver of tumorigenesis in the bladder.

Detection of nuclear foci by FISH on frozen sections of diaphragm muscle prepared from 2-month-old DMSXL mice. Detection of nuclear foci by FISH on frozen.

SIRT1 is downregulated in human gastric cancer (GC).

Nerve conduction slowing and DRG sensory neuron and nuclear atrophy in 16-week-old diabetic mice. Nerve conduction slowing and DRG sensory neuron and nuclear.

Effect of berberine on white adipose tissue mass.

Higher levels of PEDF-impaired skin structure and function.

Chop deletion preserves β-cell function in P58IPK−/− mice.

AgRP-ATF4 KO mice have decreased food intake and enhanced energy expenditure. AgRP-ATF4 KO mice have decreased food intake and enhanced energy expenditure.

Insulin resistance and hepatic steatosis in ASKO mice.

A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R mice. A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R.

Fig. 5. Loss of SMC-specific COL15A1 resulted in overall reductions in the number of YFP+ SMC-derived cells within the lesions but an increase in YFP−galectin.

Fig. 2. LUM015 fluorescently labels tumor cells in mouse models of STS and breast cancer. LUM015 fluorescently labels tumor cells in mouse models of STS.

Antitumor activity of HER2-lytic hybrid peptide in tumor xenograft model in vivo. Antitumor activity of HER2-lytic hybrid peptide in tumor xenograft model.

Hmga2 expression augments BM cells and HSCs with enhancing extramedullary hematopoiesis in JAK2V617F-induced MPN. (A) The total nuclear cell numbers from.

Rapamycin decreases PD-L1 expression in lung tumors in vivo.

MiR-200c suppresses tumor growth and metastasis of CRC in vivo by targeting Sox2. MiR-200c suppresses tumor growth and metastasis of CRC in vivo by targeting.

IL-13Rα2 expression is associated to human colon cancer progression and poor survival of patients with colorectal cancer. IL-13Rα2 expression is associated.

HCCs with overexpression of biliary/progenitor marker genes.

T-cell activation and induction of apoptosis in epithelial cells of oral lesions induced by 4-NQO. T-cell activation and induction of apoptosis in epithelial.

Combined loss of MPG and ATM sensitizes pGBM cells to temozolomide (TMZ) in vivo. Combined loss of MPG and ATM sensitizes pGBM cells to temozolomide (TMZ)

Two autopsy cases.A, Axial FLAIR (10,000/156/1) image obtained in a 63-year-old man shows grade 1 signal intensity abnormality in the anterior subependymal.

Presence of TNF and ECM degradation are consequences of abundance of macrophages in regions of ADM. A, pancreata of p48Cre;LSL-KrasG12D treated with PBS.

Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.

Pomalidomide decreases fibrosis in the lesion areas of the pancreas of KC mice. Pomalidomide decreases fibrosis in the lesion areas of the pancreas of.

PI3Kγ promotes macrophage PDGF-BB expression to control PDAC fibrosis.

Progastrin staining in colon adenomas and adenocarcinomas.

Axin induces extensive apoptosis in the lymphocytes of DDTg mice.

A 69-year-old man with small-cell carcinoma from the lung

GCS-100 selectively kills KRAS-addicted lung tumors.

Axial images from the brain of a 59-year-old woman with mixed features of response, including areas of treatment-related changes and TP. Contrast-enhanced.

Recruitment of CD8+, CD4+, and Foxp3+ cells into oral lesions in response to anti–PD-1 treatment. Recruitment of CD8+, CD4+, and Foxp3+ cells into oral.

A, Recurrent neoplasm in patient 6.

The tumorous pancreas has an abundant microbiome and its ablation is protective against pancreatic disease progression. The tumorous pancreas has an abundant.

SCLC initiated from pulmonary neuroendocrine cells metastasizes without upregulating NFIB. A and B, Mouse models of SCLC. Rb1flox/flox;Trp53flox/flox;p130flox/flox;R26mTmG.

Tumor progression is required prior to metastasis of SCLC in both CMV TKO and CGRP TKO mice. Tumor progression is required prior to metastasis of SCLC.

SCLC in CMV TKO mice arises from an alternative cell of origin.

Presentation transcript:

NIX loss delays cancer progression in KRAS-driven models of PDAC NIX loss delays cancer progression in KRAS-driven models of PDAC. A, Representative images of hematoxylin and eosin (H&E) staining of the pancreata in 9- to 12-month-old KC and KCNixΔ/Δ mice, 1.5× magnification. NIX loss delays cancer progression in KRAS-driven models of PDAC. A, Representative images of hematoxylin and eosin (H&E) staining of the pancreata in 9- to 12-month-old KC and KCNixΔ/Δ mice, 1.5× magnification. Inset image: 20× magnification. Scale bars, 200 μm. n = 5 mice per genotype. B, Quantification of the fraction of normal pancreas remaining in 9- to 12-month-old KC and KCNixΔ/Δ mice. n = 5 mice per genotype. Unpaired two-tailed t test. C, Representative images of H&E staining of the lesions found in 9- to 12-month-old KC and KCNixΔ/Δ mice. n = 5 mice per genotype. Scale bars, 100 μm. D, Classification of highest-grade PanIN lesions present in 9- to 12-month-old KC and KCNixΔ/Δ mice. n = 5 mice per genotype. E, Representative images of H&E staining of the lesions found in 4-month-old KPC and KPCNixΔ/Δ mice. n = 5 mice per genotype. Scale bars, 100 μm. F, Classification of highest-grade lesions present in 4-month-old KPC and KPCNixΔ/Δ mice. n = 5 mice per genotype. CPN, cystic papillary neoplasm. *, P < 0.05. Timothy J. Humpton et al. Cancer Discov 2019;9:1268-1287 ©2019 by American Association for Cancer Research