Molecular definitions of lung adenocarcinoma subtypes. Molecular definitions of lung adenocarcinoma subtypes. A, for each of the five tumor subtypes (acinar, papillary, solid, micropapillary, and mucinous), the frequencies of the most prevalent 10 significantly mutated genes and significantly altered CNV regions are illustrated. Each CNV region was shown as its representative gene (see Supplementary Table S7 and Supplementary Methods). B, lung adenocarcinoma subtypes are clustered according to their overall mutation profile. In the left panel, tumor subtypes are clustered by the frequencies of mutated genes. For each gene, its mutation fraction was calculated by dividing the number of patients with the mutated gene by the total number of patients included in the discovery cohort. In the right panel, tumor subtypes are clustered by the degree of the association between each subtype and the mutated genes in the subtype, as measured by Fisher exact test. Positive associations and negative associations are represented as −log10(P value; red) or log10(P value; blue), respectively. Asterisks indicate the level of significance for each association (*, P < 0.05; **, Bonferroni-adjusted P < 0.05). Seongmin Choi et al. Clin Cancer Res 2015;21:2613-2623 ©2015 by American Association for Cancer Research