IL-17A−/− mice are more susceptible to intravaginal HSV-2 challenge following intranasal immunization. IL-17A−/− mice are more susceptible to intravaginal.

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IL-17A−/− mice are more susceptible to intravaginal HSV-2 challenge following intranasal immunization. IL-17A−/− mice are more susceptible to intravaginal HSV-2 challenge following intranasal immunization. OVX WT (C57BL/6) and IL-17A−/− mice (n = 6 per group) were immunized intranasally with TK- HSV-2 (102 PFU/mouse) and 6 wk later challenged intravaginally with WT HSV-2 (5 × 103 PFU/mouse). Survival and genital pathology were monitored, and vaginal washes were collected daily for 6 d postchallenge. (A) Significance in difference in survival was calculated using the log rank (Mantel-Cox) test (*p < 0.05). (B) Genital pathology scores were recorded on a scale of 0 to 5. Data points superimposed on the x-axes of (B) indicate mice without genital pathology, and the percentages represent maximum numbers of mice that demonstrated pathology. Each symbol represents a single animal. (C) HSV-2 shedding was calculated using a Vero cell-based plaque assay, and data represent the viral loads (means ± SEMs) over 6 d. Data were analyzed using an unpaired t test with 95% confidence interval (*p < 0.05). Data shown are representative of three independent experiments with similar results. Varun C. Anipindi et al. ImmunoHorizons 2019;3:317-330 Copyright © 2019 The Authors