Synthesis and stability of radiolabeled oligonucleotides.

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Synthesis and stability of radiolabeled oligonucleotides. Synthesis and stability of radiolabeled oligonucleotides. A, Oligonucleotides modified with a 5′-amino linker were reacted with cyclic DTPA, radiolabeled with 0.2 MBq of 111In, and separated by SEC. Peak 1, radiolabeled oligonucleotides; peak 2, unreacted DTPA. B, SEC of peak 1. A single peak represents the existence of a single radiospecies. C, Oligonucleotides were radiolabeled to 27 MBq/nmol and subjected to SEC immediately (92%) or after 24 hours (94%) to assess radiolysis of the construct. CPM, counts per minute. Mark R. Jackson et al. Cancer Res 2019;79:4627-4637 ©2019 by American Association for Cancer Research