Pemetrexed (Pmx) nephrotoxicity may result from proximal tubular cell uptake of drug through apical (folate receptor-α [FR-α]) and basolateral (reduced.

Slides:

Advertisements

Similar presentations

In normal individuals, amino acids gain access to the proximal nephron cells (left-hand arrows) through the apical microvilli or through the infoldings.

Advertisements

محاضرة عامة التقنيات الحيوية (هندسة الجينات .. مبادئ وتطبيقات)

Positive interactions between the basic and translational research, clinical research, patient care, and training components of an academic dialysis access.

Tubulointerstitial Injury Associated With Chemotherapeutic Agents

Driving change: kidney proximal tubule CSF-1 polarizes macrophages

Andrew M. Hall, MD, PhD, Bruce M

Toxic Nephropathies: Core Curriculum 2010

The Cell Theory.

Apical membrane handling of substances, in this example aminoglycosides, by proximal tubular cells. Apical membrane handling of substances, in this example.

Kidney specific factors that enhance nephrotoxic risk are noted.

Replication life cycle of HIV and sites of antiretroviral drug action.

Pharmacology behind Common Drug Nephrotoxicities Perazella, Mark A

Volume 83, Issue 4, Pages (April 2013)

Transcellular movement of organic cations (OCs) and organic anions (OAs) in kidney proximal tubule epithelial cells. Transcellular movement of organic.

Mechanism of action of drugs commonly used to treat hyponatremia.

Conceptual model of the natural history of diabetic kidney disease.

Renal proximal tubular catabolism of glutamine.

Driving change: kidney proximal tubule CSF-1 polarizes macrophages

Cast nephropathy. Cast nephropathy. Schematic diagram illustrating the pathophysiology of AKI in cast nephropathy. Free light chains filtered by the glomerulus.

Volume 84, Issue 2, Pages (August 2013)

Impact of FeD and FeS on isolated tubule mitochondrial energetics, as assessed by ATP/ADP ratios. Impact of FeD and FeS on isolated tubule mitochondrial.

New drug toxicities in the onco-nephrology world

Volume 60, Issue 2, Pages (August 2001)

Advances in the pathogenesis of HIV-associated kidney diseases

KHA and response. KHA and response. KHA includes AKI history, BP, CKD, serum Creatinine level, Drug list, and urine Dipstick (ABCD). Exposures include.

Aquaporins in the kidney: Emerging new aspects

Latest findings in phosphate homeostasis

Mineral metabolism in CKD: adaptation devolves into maladaptation.

Study of isolated perfused tubular segments allowed study of each of the different nephron segments independently. Study of isolated perfused tubular segments.

A new regulator of the vacuolar H+-ATPase in the kidney

(A) Mean (SD) serum continuous erythropoietin receptor activator (C. E

Volume 72, Issue 4, Pages (August 2007)

Engineering of Chimeric Antigen Receptor therapy.

Model of proximal ammonia transport.

Proximal tubule HCO3− reabsorption and H+ secretion.

Reduced Folate Carrier and Folylpolyglutamate Synthetase, but not Thymidylate Synthase Predict Survival in Pemetrexed-Treated Patients Suffering from.

Ammonia secretion by the collecting duct.

Conditions within the kidney that are conducive to C activation.

Drug factors associated with increased risk for nephrotoxicity.

Key apical membrane ion transporters and channels in various segments of the gastrointestinal tract. Key apical membrane ion transporters and channels.

Mean plasma concentrations of ampicillin/sulbactam in plasma of critically ill patients with AKI undergoing extended dialysis (duration depicted by box.

Ca2+ infusion rates during all three protocol versions.

The Ussing Chamber can be used to measure ion transport between the two sides of an epithelial cell membrane by polarized cells. The Ussing Chamber can.

Basolateral transport of drugs.

Carboxylation of vitamin K–dependent proteins requires the reduced form of vitamin K, γ-glutamyl carboxylase enzyme, molecular oxygen, and carbon dioxide.

Drug clearance by metabolism can also decrease with declining kidney function. Drug clearance by metabolism can also decrease with declining kidney function.

Apical transport of drugs in the proximal tubule.

Patient factors that increase risk for drug-induced nephrotoxicity.

Bisphosphonate nephrotoxicity

Cetuximab (C) is an EGF receptor (EGFR) antibody that causes renal magnesium wasting by competing with EGF for its receptor. Cetuximab (C) is an EGF receptor.

The proximal kidney tubule is the target for tenofovir-associated nephrotoxicities. The proximal kidney tubule is the target for tenofovir-associated nephrotoxicities.

Potential roles of biomarkers

Urea transport across an IMCD cell.

Intercalated cells are involved in K+secretion in the collecting duct

Algorithm for management of drug-induced acute interstitial nephritis

Urea transporters along the nephron.

Kidney factors that enhance risk for drug-induced nephrotoxicity.

Cisplatin (Cis) nephrotoxicity is, in part, related to its uptake by proximal tubular cells. Cisplatin (Cis) nephrotoxicity is, in part, related to its.

Integrated overview of renal ammonia metabolism.

Model of major transport processes and regulatory mechanisms in type B intercalated cells. Model of major transport processes and regulatory mechanisms.

Volume 5, Issue 1, Pages 5-6 (January 2007)

A glomerulus exhibits mesangiolysis, endothelial denudation, red blood cell congestion, and glomerular basement membrane duplication in this example of.

Pathophysiologic pathways of hematuria-induced kidney damage.

A decision matrix for readers, reviewers, and guideline makers to conceptualize results-based and process-based merits in clinical trials. A decision matrix.

A glomerulus exhibits global wrinkling and retraction of the glomerular basement membrane and diffuse swelling and hyperplasia of overlying visceral epithelial.

Lithium transport pathways in proximal and distal tubule cells.

Speculative mechanism by which gadolinium (Gd3+) might trigger nephrogenic systemic fibrosis. Speculative mechanism by which gadolinium (Gd3+) might trigger.

A urine sediment score of 0–4 is used to quantitatively evaluate AKI

Regulation of serum calcium homeostasis.

The cell model illustrates β2-adrenergic and insulin-mediated regulatory pathways for K+ uptake. β2-Adrenergic and insulin both lead to K+ uptake by stimulating.

Presentation transcript:

Pemetrexed (Pmx) nephrotoxicity may result from proximal tubular cell uptake of drug through apical (folate receptor-α [FR-α]) and basolateral (reduced folate carrier [RFC]) transporters. Pemetrexed (Pmx) nephrotoxicity may result from proximal tubular cell uptake of drug through apical (folate receptor-α [FR-α]) and basolateral (reduced folate carrier [RFC]) transporters. After it is inside the cell, Pmx is polyglutamylated, which inhibits drug transport out of the cell and enhances drug inhibition of folate metabolism. Impaired synthesis of RNA and DNA by cells causes clinical AKI and tubulopathy. Pmx-glt, polyglutamylated pemetrexed. Mark A. Perazella CJASN 2012;7:1713-1721 ©2012 by American Society of Nephrology