The activation of PKC-δ and JNK1 is essential for doxorubicin-induced senescence. The activation of PKC-δ and JNK1 is essential for doxorubicin-induced.

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Figure S1. qPCR analysis of the EMT markers ZEB2 and SNAI1 in Syndecan-1 and control siRNA transfected MDA-MB-231 and MCF-7 cells reveals no significant.

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The activation of PKC-δ and JNK1 is essential for doxorubicin-induced senescence. The activation of PKC-δ and JNK1 is essential for doxorubicin-induced senescence. MCF7 cells were treated with rottlerin or SP600125 at the indicated times following doxorubicin treatment, and SA-β-Gal activity was analyzed 6 d later. A. Intervals when rottlerin affected doxorubicin-induced senescence. B. Intervals when SP600125 affected doxorubicin-induced senescence. Sae Lo Oom Lee et al. Mol Cancer Res 2009;7:1845-1853 ©2009 by American Association for Cancer Research