A glomerulus exhibits global wrinkling and retraction of the glomerular basement membrane and diffuse swelling and hyperplasia of overlying visceral epithelial cells in this example of collapsing focal segmental glomerulosclerosis. A glomerulus exhibits global wrinkling and retraction of the glomerular basement membrane and diffuse swelling and hyperplasia of overlying visceral epithelial cells in this example of collapsing focal segmental glomerulosclerosis. (Jones methenamine silver stain; original magnification, ×600.) Courtesy of Glen S. Markowitz. Mark A. Perazella CJASN 2012;7:1713-1721 ©2012 by American Society of Nephrology