Fig. 1. GDF15 is up-regulated with obesity, and AAV-GDF15 improves metabolic parameters in DIO mice. GDF15 is up-regulated with obesity, and AAV-GDF15.

Slides:

Advertisements

Similar presentations

The FATZO mouse as a Translational Model for the Development of Drugs for Obesity, Metabolic Syndrome and Diabetes. PreClinOmics, Inc. 1.

Advertisements

Fig. 3. Fc fusion GDF15 molecules improve metabolic parameters in obese mice and obese cynomolgus monkeys. Fc fusion GDF15 molecules improve metabolic.

Basic design concept of human mimetic humanoid.

TPAD controller performance for three force components.

Three different types of transfer functions with a codomain of [0,1].

TPAD training protocol.

Improvement in the transcriptional activity of FOXP3A384T by enhancement of TIP60-FOXP3 interaction. Improvement in the transcriptional activity of FOXP3A384T.

T2-weighted cross-sectional MR imaging of MSP swarms inside SD rats.

Group data during free walking between sessions 1 and 16.

Deficiency in myeloid-resident NRP1 affects systemic metabolism.

NRP1-expressing myeloid cells influence adipocyte hypertrophy, development of fatty liver, and CLSs. NRP1-expressing myeloid cells influence adipocyte.

Transfer of NRP1-expressing bone marrow improves the metabolic phenotype of LysM-Cre-Nrp1fl/fl mice. Transfer of NRP1-expressing bone marrow improves the.

Fig. 7 Correlation of NHP and human ISGs.

Fig. 6 In utero injection of inflammatory cytokines or adoptive transfer of activated T cells leads to pregnancy loss. In utero injection of inflammatory.

Fig. 4 The extracellular domain of sortilin is sufficient for BDNF/TrkB signaling. The extracellular domain of sortilin is sufficient for BDNF/TrkB signaling.

Fig. 5 Quantitative assessment of the efficacy of the tissue-engineered implant to heal the TMJ disc defect. Quantitative assessment of the efficacy of.

Fig. 1 ZIKV RNA in blood and tissues.

Fig. 2 Whisker deprivation accelerates and enhances behavioral recovery after right S1FP photothrombosis. Whisker deprivation accelerates and enhances.

Cell viability tests. Cell viability tests. SEM images of (A) MC3T3-E1 cells and (B) MSCs on days 1, 3, and 5 of culture. (C) Survival rates of MC3T3-E1.

Fluorescence properties of MSP.

T2-weighted cross-sectional MR imaging of MSP swarms inside SD rats.

Fig. 3 ROC curves of mCCNA1 and mVIM assayed in esophageal cytology brushings from control normal-appearing GE junctions versus BE and EAC cases. ROC curves.

Fig. 3 M7824 inhibits tumor growth and metastasis and provides long-term antitumor immunity. M7824 inhibits tumor growth and metastasis and provides long-term.

Fig. 2 Preserved long-term functionality of the TEHVs over 1-year follow-up as assessed by ICE and cardiac MRI flow measurements. Preserved long-term functionality.

Platelet-released serotonin contributes to hypothermia in mice undergoing HA-hIgG–dependent anaphylaxis. Platelet-released serotonin contributes to hypothermia.

Fig. 3 Liver stiffness and NT-proBNP concentration after treatment with miridesap followed by dezamizumab. Liver stiffness and NT-proBNP concentration.

In vivo release of doxycycline hyclate from the GRS in a swine model

Fig. 5. In vivo characterization of adipogenesis by CT.

Fig. 4 Deletion of hepatocyte HIF-2α does not affect obesity-induced glucose, glucagon, and insulin intolerance. Deletion of hepatocyte HIF-2α does not.

Fig. 3 Glucose- and structure-dependent insulin release.

MϕRIP140KD mice exhibit improved metabolic phenotypes.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 3. Increased expression of exhaustion markers and apoptosis markers on CAR8 cells in the presence of TCR antigen. Increased expression of exhaustion.

Fig. 1. CAR4 and CAR8 cells demonstrate in vitro and in vivo antileukemic efficacy. CAR4 and CAR8 cells demonstrate in vitro and in vivo antileukemic efficacy.

Fig. 2. Effects of SFN in mouse hepatocytes and in rat models of diet-induced glucose intolerance. Effects of SFN in mouse hepatocytes and in rat models.

Results of a representative participant with multiple training sessions. Results of a representative participant with multiple training sessions. Average.

AEGIS autonomous targeting process.

Fig. 3 Measurement of real-world, high-risk opioid use events.

Fig. 3 Local Maraba treatment of TNBC tumors provides long-term systemic protection. Local Maraba treatment of TNBC tumors provides long-term systemic.

Fig. 5 A holistic formula TNTL targeting SBP2 in ATMs improved insulin resistance in obese mice. A holistic formula TNTL targeting SBP2 in ATMs improved.

Fig. 3 Loss of SBP2 in obesity exacerbated insulin resistance and adipogenesis. Loss of SBP2 in obesity exacerbated insulin resistance and adipogenesis.

Representative CT and PET/CT images of three patients with NSCLCs

Fig. 1. The HCN channel blocker ivabradine (IVA) is analgesic in a mouse model of type 1 diabetes. The HCN channel blocker ivabradine (IVA) is analgesic.

Fig. 2. PlGF-2123–144 conjugation reduces systemic exposure to checkpoint blockade Abs and potential treatment-related toxicity. PlGF-2123–144 conjugation.

Fig. 3 LRRK2 activation in nigrostriatal dopamine neurons in two rat models of PD. LRRK2 activation in nigrostriatal dopamine neurons in two rat models.

Fig. 4 Overexpression of SBP2 improved insulin sensitivity and suppressed adipogenesis in obese mice. Overexpression of SBP2 improved insulin sensitivity.

Fig. 4 Dox-CBD-SA treatment shows reduced toxicity.

Fig. 2 Effect of CSF sTREM2– and CSF sTREM2–to–p-tau181 ratio on changes in cognition. Effect of CSF sTREM2– and CSF sTREM2–to–p-tau181 ratio on changes.

Fig. 5. Vascularization of human liver seed grafts.

Fig. 3. Human liver tissue seed graft function.

Fig. 3 Mmp-2−/− mice are protected from obesity and leptin resistance.

Fig. 2 Neonatal ZIKV infection induces seizures in young mice and increases susceptibility to chemically induced seizures in adult mice. Neonatal ZIKV.

Fig. 2 In vitro and preclinical study with 18F-MPG.

Fig. 2. Human liver tissue seed grafts expand after host liver injury.

Fig. 7 Heart-specific OMA1 down-regulation protects from hypertrophy induced by TAC. Heart-specific OMA1 down-regulation protects from hypertrophy induced.

Fig. 5. High burdens of AA signature mutations and predicted immunogenicity in Taiwan HCCs. High burdens of AA signature mutations and predicted immunogenicity.

Effects of highly concentrated SFN provided as BSE in T2D patients

Fig. 1. Construction of human liver seed grafts.

IL-33 is not critical for initiation of allergic airways disease phenotype. IL-33 is not critical for initiation of allergic airways disease phenotype.

Fig. 7 BEL immune response.

Fig. 2. Mechanism of PD-L1 down-regulation in NOD HSPCs.

Fig. 2 NGS bisulfite sequencing assay of DNA methylation in esophageal biopsies. NGS bisulfite sequencing assay of DNA methylation in esophageal biopsies.

Fig. 6 TNF-α neutralization prevents ZIKV-induced seizures in mice.

Fig. 4 Gallium increases P. aeruginosa sensitivity to peroxides.

Meningeal γδ T cell homeostasis is independent of inflammatory signals

Fig. 2 Daily TNC pickups and drop-offs for an average Wednesday in fall 2016 (1). Daily TNC pickups and drop-offs for an average Wednesday in fall 2016.

Fig. 6 Pharmacologic alterations of β-AR signaling regulate cardiomyocyte abscission and endowment. Pharmacologic alterations of β-AR signaling regulate.

Fig. 3. Effects of SFN in mice with diet-induced diabetes.

Fig. 2 Astrocyte-specific AAV2/5 RiboTag.

Fig. 2 Time series of secularization versus GDP per capita, from four illustrative countries, over the 20th century. Time series of secularization versus.

Presentation transcript:

Fig. 1. GDF15 is up-regulated with obesity, and AAV-GDF15 improves metabolic parameters in DIO mice. GDF15 is up-regulated with obesity, and AAV-GDF15 improves metabolic parameters in DIO mice. (A) Microarray signal intensity of GDF15 in the liver and fat tissues from C57BL/6 and ob/ob mice (n = 5 to 6). (B) Serum GDF15 concentrations in lean and obese mice (n = 5 to 8), rats (n = 5 to 6), and humans (n = 16). (C) Body weight, average daily food intake 1 month after AAV-hGDF15 injection; glucose, insulin, triglyceride, and cholesterol concentrations 5 months after AAV injection; and serum hGDF15 concentrations 12, 81, and 350 days after AAV injection in male B6D2F1 DIO mice injected with empty vector or AAV-hGDF15 (n = 5 to 15). (D) Fat mass, lean mass, and bone mineral density of 18-month-old male B6D2F1 DIO mice injected with empty vector 12 months after AAV injection, 18-month-old male B6D2F1 DIO mice injected with AAV-hGDF15 12 months after AAV injection, and a group of untreated 12-week-old mice on normal chow (n = 3). *P < 0.05, **P < 0.01, and ***P < 0.001 versus empty vector by analysis of variance (ANOVA). Yumei Xiong et al., Sci Transl Med 2017;9:eaan8732 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works