DCRunx3−/− mice resistance to DMBA/TPA–induced tumorigenesis.

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DCRunx3−/− mice resistance to DMBA/TPA–induced tumorigenesis. DCRunx3−/− mice resistance to DMBA/TPA–induced tumorigenesis. A, DCRunx3−/− mice characterization. Left, PCR showing specific deletion of the floxed Runx3 alleles (268-bp amplicon) in sorted dDCs from a DCRunx3−/− mouse (PCR details in Supplementary Fig. S1). Right, reduced yield (multiplicity) and extended time to first papilloma in DCRunx3−/− (n = 8), compared with WT (n = 21) mice (P < 0.01), and comparable papilloma rates in DCRunx3−/− and control mice. B, detection of morphologically mature LCs in DCRunx3−/− epidermis. Left, MHCII-FITC immunostained epidermal sheets. Right, quantitative analysis of epidermal LCs (n = 4 mice/genotype, ≥5 fields/mouse at ×400 magnification). *, P < 0.01; scale bars, 20 μm. Bottom, flow cytometry analysis of LCs (CD11c+/MHCII+) isolated from DCRunx3−/− (left) or control littermate (right) epidermal cell suspensions. Results represent one of four DCRunx3−/− or littermate control mice with similar findings. Values in A and B are mean ± SD. Omri Bauer et al. Cancer Prev Res 2014;7:913-926 ©2014 by American Association for Cancer Research