A summary of the average level of methylation of selected MCA/RDA MICPs by bisulfite-modified genomic sequencing. A summary of the average level of methylation.

Slides:

Advertisements

Similar presentations

Kuhlmann et al. Suppl. Figure 4 A bisulfite sequencing CG CHG CHH Δ open: unmethylated filled: methylated.

Advertisements

The virochip (UCSF) is a spotted microarray. Hybridization of a clinical RNA (cDNA) sample can identify specific viral expression.

Supplemental Figure 1. A typical KRAS Sanger dye termination sequencing trace for a pancreatic cancer sample. The arrow indicates the mutation site; the.

Genome evolution within the individual

Homozygous deletions within chromosome 9q23.

Figure 1. MORT gene silencing is early event in cancer

Genomics in Primary and Secondary Prevention of Pancreatic Cancer

IHC analyses of levels and/or phosphorylation status of selected proteins from representative sections of ventral prostate of Hi-Myc mice. IHC analyses.

Primary care physicians visited chiefly by black patients were more likely to report they were unable to provide high-quality care to all their patients.

High-throughput analysis of informative CpG sites for the four studied tumor suppressor genes (A-D). High-throughput analysis of informative CpG sites.

Quantitative PCR of CRTAC1 (white columns) and WASF1 (black columns) loci in germ line DNA (A), glomus tumor no. 1 (B), and glomus tumor no. 3 (C) from.

Volume 123, Issue 1, Pages (July 2002)

Patient characteristics: American vs Canadian transplant patients

Distribution of informative SNPs with LOH (black bars) on each chromosome (rows, oriented p-arm at the bottom and q-arm at the top of each chromosome)

Number of 0.5-Mb windows with chromosome lesions that reached statistical significance across patients in early (BE early and BE instability) and late.

A, genomic copy number profiles of chromosome 8 with array CGH in SUM-44, -52, and A, genomic copy number profiles of chromosome 8 with array CGH.

The human GPR109A promoter is methylated and GPR109A expression is silenced in human colon carcinoma cells. The human GPR109A promoter is methylated and.

Temporal order of mutational processes during cancer evolution.

Retinal nerve fibre layer (RNFL) thickness versus age in patients with WFS (white dots) and in age-matched normal subjects (black dots). Retinal nerve.

Manhattan plot for the association between COPD and DNA methylation in never smokers (left) and current smokers (right). Manhattan plot for the association.

Comparison of the percentages of ducts in the pancreas containing cells showing positive staining for the different markers between control patients and.

The TSDR of ATL cells exhibits Treg-like hypomethylated status or CD4+ conventional T cell–like methylated status. The TSDR of ATL cells exhibits Treg-like.

BRCA1 promoter methylation detected in the peripheral blood and corresponding tumor. BRCA1 promoter methylation detected in the peripheral blood and corresponding.

Expression analysis of IGFBP-3 using human whole-genome microarray.

Methylation status of IGFBPL1 in human breast cancer.

DNA hypermethylation silences TRAIL in transformed cells.

Combination extract inhibits NF-κB activation in intestine, liver, testis, and epididymis. Combination extract inhibits NF-κB activation in intestine,

Schematic of experimental parameters comparing FFPE DNA repair methods to FF DNA. DNA (500 ng) from FF tissue was processed according to Illumina Human.

Integrated mRNA and microRNA expression and DNA methylation clusters.

A, Overall survival of patients treated with CAR T cells (black line; n = 15). A, Overall survival of patients treated with CAR T cells (black line; n.

Colony-forming capacity of CD34+ cells with and without CLL-1 expression. Colony-forming capacity of CD34+ cells with and without CLL-1 expression. CD34+

A, scatterplots of qMSP analysis of candidate genes promoters in the prevalence screen cohort, which consisted of 55 HNSCC tumor tissue samples and 37.

Effect of nicotinamide and carbogen on 5-FU uptake (measured as SUV3

Presentations of thyroid disorders after receiving immune checkpoint inhibition combination therapy or monotherapy. Presentations of thyroid disorders.

Correlation between serum visfatin concentrations and the clinical stage (A) and tumor size (B, C) of HCCs. A and B, the correlations were determined by.

A and B, images from a patient with an invasive carcinoma on the floor of the mouth. A and B, images from a patient with an invasive carcinoma on the floor.

Genomic location of 11 genes in relation to the CTD-2019C10 BAC clone.

Study overview. Study overview. A, Schematic illustrating clinical trial design and the nature and number of tissue specimens available for downstream.

FILM protein signature predicts poor survival in nontreated stage-IB lung adenocarcinoma. FILM protein signature predicts poor survival in nontreated stage-IB.

Expression of S100A11 in bulk pancreatic tissues (pancreatic cancer, n = 22; IPMN, n = 18; nonneoplastic pancreas, n = 22). Expression of S100A11 in bulk.

Kaplan-Meier survival analysis of p53 mutation in the overall breast tumor series. Kaplan-Meier survival analysis of p53 mutation in the overall breast.

Establishment of MajSAT RNA–expressing mice.

Methylation-specific PCR of APC, RASSF1A, and p14ARF genes in bladder tumor and urine DNAs. In the APC gel panel viewed from left to right, the first (TCC34)

Reduced klotho expression in pancreatic cancer.

Representative images demonstrating LOH in breast cancer patients’ paired BM aspirate and primary tumors (T) at D14S62, D14S51, and D8S321, respectively.

Pancreatic adenocarcinoma, chronic pancreatitis, and normal pancreas samples can be distinguished on the basis of gene expression profiling. Pancreatic.

A 63-year-old female with lung adenocarcinoma treated with nivolumab, who experienced pseudoprogression. A 63-year-old female with lung adenocarcinoma.

ODC protein expression in paired benign and cancer tissue obtained from patients with PCA. The protein expression was measured by immunoblot analysis in.

Efficacy summary for patients with gastric/GEJ adenocarcinoma (part B)

Pomalidomide decreases fibrosis in the lesion areas of the pancreas of KC mice. Pomalidomide decreases fibrosis in the lesion areas of the pancreas of.

A, pretreatment CT scan of pelvic lymphadenopathy (identified by white arrow) in 1 patient with documented response to 1α-OH-D2. A, pretreatment CT scan.

Mean percentage change from baseline in total IGF-I and the R1507 serum concentration values following a single i.v. administration of R mg/kg (n.

ROC analysis of MIC-1 and CA19-9.

Progastrin staining in colon adenomas and adenocarcinomas.

The best response for target lesions per patient for patients with target lesions assessed at baseline and at least 1 follow-up. The best response for.

Biodistributions 24 hours after injection of different 177Lu-chCE7F(ab′)2 conjugates ( MBq, 13 μg) in tumor-bearing nude mice: effect of the number.

Gastric, lung, and HPV-related cancer incidence and model fits.

Validation of NAA's cancer specificity in lung cancer.

Methylation targets of TET1 in vitro.

Measurements of the apoptotic response of CLL cells to radiation and the association with elevated genomic complexity. Measurements of the apoptotic response.

Relative frequencies of FGFR aberrations in non–small cell lung carcinoma. Relative frequencies of FGFR aberrations in non–small cell lung carcinoma. A,

Cells expressing mutant NADK-I90F exhibit low ROS and elevated NADP and NADPH levels. Cells expressing mutant NADK-I90F exhibit low ROS and elevated NADP.

Frequency and number of KLL-specific clonotypes in tumors from patients with KLL-specific T cells in PBMCs or cultured TILs. A wedge (the length of which.

Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells. Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells.

A, study design for measuring the feasibility, concordance, and accuracy of a plasma-based cfDNA sequencing test compared with biopsy-based sequencing.

Scatter plots of the posterior probability values belonging to normal and IM gastric tissue categories calculated by (A) FP; (B) HW; and (C) integrated.

Driver pathways and key genes in OSCC

Integrated analysis of gene expression and copy number alterations.

Two to 20 years: female patients, continued.

GSN and DNMT1 expression are inversely correlated in a pattern associated with patient survival. GSN and DNMT1 expression are inversely correlated in a.

Presentation transcript:

A summary of the average level of methylation of selected MCA/RDA MICPs by bisulfite-modified genomic sequencing. A summary of the average level of methylation of selected MCA/RDA MICPs by bisulfite-modified genomic sequencing. The specimen number and the age of the patients are in the left column. Empty oval, 0–10% methylation; white oval with black dots, 11–30% methylation; black oval with white dots, 31–70% methylation; black oval, 71–100% methylation; ·, not determined. NP, normal pancreas; PCa, primary pancreatic adenocarcinoma. Takashi Ueki et al. Cancer Res 2001;61:8540-8546 ©2001 by American Association for Cancer Research