Fig. 7 Heart-specific OMA1 down-regulation protects from hypertrophy induced by TAC. Heart-specific OMA1 down-regulation protects from hypertrophy induced.

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Fig. 7 Heart-specific OMA1 down-regulation protects from hypertrophy induced by TAC. Heart-specific OMA1 down-regulation protects from hypertrophy induced by TAC. OPA1 processing analysis by Western blot (A) and quantification (B) in isolated mitochondria from heart and liver of mice injected with sh scrambled (shScr) or shOMA1 viral particles. Mitochondria were incubated in the presence of carbonyl cyanide m-chlorophenyl hydrazone for the indicated time points. MW, molecular weight; nt, not treated. (C) Des Ao Vel, heart weight/body weight (HW/BW), % EF, and rate of ATP synthesis in WT inbred (C57BL/6JOlaHsd) and outbred (CD1) mice injected with sh shScr or shOMA1 virus and then subjected to TAC. Analyses were performed 3 weeks after TAC surgery. (D) OPA1 processing analysis by Western blot (left) and quantification OPA1 (right) in mitochondrial heart fractions form WT inbred (C57BL/6JOlaHsd) and outbred (CD1) mice injected with sh scr or sh OMA1 for the indicated conditions. Data are given as scatter dot plots, and lines are means ± SD. Differences assessed by one-way ANOVA and Tukey’s multiple comparison test. N as described in table S1; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. Rebeca Acin-Perez et al., Sci Transl Med 2018;10:eaan4935 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works