Sturm und Drang over Suicidal Lymphocytes

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Sturm und Drang over Suicidal Lymphocytes Michel Sadelain, Isabelle Rivière Molecular Therapy Volume 5, Issue 6, Pages 655-657 (June 2002) DOI: 10.1006/mthe.2002.0619 Copyright © 2002 American Society for Gene Therapy Terms and Conditions

FIG. 1 Examples of oncoretroviral vectors used to transfer “suicide” genes into T lymphocytes. (A) HyTK contains the 5′ LTR Moloney murine sarcoma virus (MSV) long terminal repeat (LTR), the Moloney murine leukemia virus (MLV) from pLNL6 as 3′ LTR, and the HyTK selectable fusion gene [2]. (B) pMX LVVFas encodes a ΔLNGFR/FAS fusion gene inserted into the pMX retroviral vector modified to include a puromycin (PURO) resistance gene [3]. Details of construct are not available. (C) G1TkSvNa contains the HSVTK gene under the transcriptional control of the 5′ LTR and the neomycin phosphotransferase gene (NEO) under the control of the simian virus (SV40) early promoter [4]. (D) SFCMM3 is derived from the LXSN and SFCM-2 vectors and encodes the HSVTK gene under the transcriptional control of the 5′ chimeric LTR and ΔLNGFR under the transcriptional control of the SV40 early promoter [5]. (E) NIT is a Mo-MLV-based vector derived from pMFG that encodes NTP and HSVTK as a bicistronic transcription unit [6]. The NTP marker [6,31] is truncated of the cytoplasmic domain of p75/LNGFR and mutated by linker insertion (*) to abolish NGF binding [32]. Molecular Therapy 2002 5, 655-657DOI: (10.1006/mthe.2002.0619) Copyright © 2002 American Society for Gene Therapy Terms and Conditions