N1 decoys reduced perfusion and JAG-specific decoys disrupted pericyte association in Mm5MT-FGF4 tumors. N1 decoys reduced perfusion and JAG-specific decoys.

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N1 decoys reduced perfusion and JAG-specific decoys disrupted pericyte association in Mm5MT-FGF4 tumors. N1 decoys reduced perfusion and JAG-specific decoys disrupted pericyte association in Mm5MT-FGF4 tumors. A, endomucin staining of FITC-lectin perfused tumors. B, antibody detection of tumors from hypoxyprobe-injected mice and costained with 4,6-diamidino-2-phenylindole (DAPI). C, quantitation of vessel perfusion by the mean percentage of the lectin-positive area ± SD; *, P < 0.006 (n = 4–5). D, quantitation of the mean percentage of the hypoxyprobe-positive area ± SD; *, P < 0.002 and **, P < 0.05 (n = 4–5). E, collagen type IV (ColIV) and endomucin staining of Mm5MT-FGF4 tumor sections; A, B, and E, scale bars, 30 μm. F, quantification of the mean collagen type IV-positive area divided by the mean endomucin-positive area, ± SD; (n = 4–5). G, quantification of the mean NG2-positive area divided by the mean endomucin-positive area, ± SD; *, P < 0.02 (n = 4–5). H, endomucin and NG2 staining of Mm5MT-FGF4 tumor sections; scale bars, 10 μm. Thaned Kangsamaksin et al. Cancer Discovery 2015;5:182-197 ©2015 by American Association for Cancer Research