miR can promote cardiomyocyte proliferation in the adult heart

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Date of download: 6/21/2016 Copyright © The American College of Cardiology. All rights reserved. From: Human Ventricular Unloading Induces Cardiomyocyte.

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Fig. 5. miR302-367 can promote cardiomyocyte proliferation in the adult heart. miR302-367 can promote cardiomyocyte proliferation in the adult heart. (A) Schematic of tamoxifen-inducible miR302-367 overexpression in the hearts of adult Myh6mercremer mice. (B to D) Confocal images with z-stacking and quantification showing the number of cells reentering the cell cycle [5-bromo-2′-deoxyuridine (BrdU)+] (B), undergoing mitosis (PH3+) (C), or undergoing cytokinesis [Aurora B (AuB)+] (D) 7 days after induction of miR302-367 expression in the adult heart. (E) Number of cardiomyocytes in Myh6mercremer and Myh6mercremer:R26R-miR302-367Tg/+animals. Inset: Fluorescence-activated cell sorting (FACS) plot shows that 98.6% of the isolated cells counted in the adult hearts are cTnT+ cardiomyocytes. (F) Number of nuclei in control and Myh6mercremer:R26R-miR302-367Tg/+ cardiomyocytes. Scale bars, 100 μm. mono, mononucleated; bi, binucleated; multi, multinucleated About 1 × 103 cardiomyocytes were counted per sample. (G) Cell sizes of the isolated cardiomyocytes. Data are means ± SEM (n = 3). P values determined with Student’s t test. n.s., no significant change. Ying Tian et al., Sci Transl Med 2015;7:279ra38 Copyright © 2015, American Association for the Advancement of Science