A, cell number was assessed 96 hours after exposure to indicated treatment in indicated cell models. A, cell number was assessed 96 hours after exposure to indicated treatment in indicated cell models. Treatments were ABT888 (2.5 mmol/L), IR (2 Gy), ABT888 + IR (2.5 mmol/L + 2 Gy), DCTX (1 nmol/L DCTX), and ABT888 + DCTX (2.5 mmol/L + 1 nmol/L DCTX). Vehicle control is set to “100%.” B, model systems indicated were treated with vehicle control (solid line) or 2.5 mmol/L ABT888 (dashed line), and cell number was assessed at indicated time points. Cell number at the 0 hour time point is set to “1.” Data reflect averages and SD of at least 3 independent experiments, each conducted with biologic triplicates. Statistical significance was determined using Student t test. *, P < 0.05; **, P < 0.01; ***, P < 0.001. PCa, prostate cancer. Matthew J. Schiewer et al. Cancer Discovery 2012;2:1134-1149 ©2012 by American Association for Cancer Research