Warfarin Pharmacogenetics: CYP2C9 and VKORC1 Genotypes Predict Different Sensitivity and Resistance Frequencies in the Ashkenazi and Sephardi Jewish.

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Presentation transcript:

Warfarin Pharmacogenetics: CYP2C9 and VKORC1 Genotypes Predict Different Sensitivity and Resistance Frequencies in the Ashkenazi and Sephardi Jewish Populations Stuart A. Scott, Lisa Edelmann, Ruth Kornreich, Robert J. Desnick The American Journal of Human Genetics Volume 82, Issue 2, Pages 495-500 (February 2008) DOI: 10.1016/j.ajhg.2007.10.002 Copyright © 2008 The American Society of Human Genetics Terms and Conditions

Figure 1 Schematic of the CYP2C9 and VKORC1 Genes The locations of the nucleotide variations and missense mutations analyzed in this study are noted and are based on accession numbers M61857 and AY587020. The g.-1639G→A (rs9923231), g.3730G→A (rs7294), and g.698C→T (rs17708472) tag-SNPs for the VKORC1∗2,∗3, and ∗4 haplotypes correspond to 3673G→A, 9041G→A, and 6009C→T (accession number AY587020), respectively. Illustrations are not to scale. The American Journal of Human Genetics 2008 82, 495-500DOI: (10.1016/j.ajhg.2007.10.002) Copyright © 2008 The American Society of Human Genetics Terms and Conditions