Biodistributions 24 hours after injection of different 177Lu-chCE7F(ab′)2 conjugates (1.5-3.0 MBq, 13 μg) in tumor-bearing nude mice: effect of the number.

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Biodistributions 24 hours after injection of different 177Lu-chCE7F(ab′)2 conjugates (1.5-3.0 MBq, 13 μg) in tumor-bearing nude mice: effect of the number of chelators coupled to F(ab′)2. Biodistributions 24 hours after injection of different 177Lu-chCE7F(ab′)2 conjugates (1.5-3.0 MBq, 13 μg) in tumor-bearing nude mice: effect of the number of chelators coupled to F(ab′)2. White columns, 177Lu-DOTA-chCE7F(ab′)2 [five chelators/F(ab′)2]; black columns, 177Lu-DOTA-chCE7F(ab′)2 [three chelators/F(ab′)2]; striped columns, 177Lu-DOTA-triglycine-chCE7F(ab′)2 [two chelators/F(ab′)2]. Data are %ID/g ± SD (n = 3) for the DOTA-conjugates (n = 8) for the DOTA-triglycine conjugate. Jürgen Grünberg et al. Clin Cancer Res 2005;11:5112-5120 ©2005 by American Association for Cancer Research