Accessories to Limb Regeneration

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Accessories to Limb Regeneration Yanchao Han, Kenneth D. Poss Developmental Cell Volume 37, Issue 4, Pages 297-298 (May 2016) DOI: 10.1016/j.devcel.2016.05.007 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 A Model of Salamander Accessory Limb Formation The formation of an accessory limb requires three components: a lateral wound in the upper limb, a nerve deviated to the wound, and a skin graft from the opposite (in this case, posterior) side. Nerve deviation converts skin wound healing to blastema formation, whereas juxtaposition of anterior and posterior tissues provides positional information for blastemal patterning and outgrowth of an accessory limb. Nerve-derived BMP/FGF signals, anterior FGF signal, and posterior SHH signal are required in these processes. Artwork by A. Dickson. Developmental Cell 2016 37, 297-298DOI: (10.1016/j.devcel.2016.05.007) Copyright © 2016 Elsevier Inc. Terms and Conditions