Efficacy of live oral rotavirus vaccines by duration of follow-up: a meta-regression of randomised controlled trials Andrew Clark, PhD, Kevin van Zandvoort,

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Efficacy of live oral rotavirus vaccines by duration of follow-up: a meta-regression of randomised controlled trials Andrew Clark, PhD, Kevin van Zandvoort, MSc, Stefan Flasche, PhD, Prof Colin Sanderson, PhD, Prof Julie Bines, MD, Jacqueline Tate, PhD, Umesh Parashar, MD, Prof Mark Jit, PhD The Lancet Infectious Diseases Volume 19, Issue 7, Pages 717-727 (July 2019) DOI: 10.1016/S1473-3099(19)30126-4 Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 1 Median and 95% credible intervals of cumulative and instantaneous vaccine efficacy by duration of follow-up and setting after two or three doses of oral rotavirus vaccination (infant schedules only) A simple power function was used to represent vaccine waning over time; equivalent plots based on other potential waning functions are available in the appendix (p 10). Each blue dot represents the VE for each observation. The size of the dot represents the relative sample size of the study. The error bars represent 95% CIs around the VE. VE=vaccine efficacy. The Lancet Infectious Diseases 2019 19, 717-727DOI: (10.1016/S1473-3099(19)30126-4) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 2 Median and 95% credible intervals of cumulative and instantaneous vaccine efficacy by duration of follow-up and type of schedule (neonatal vs infant) following three doses of RV3-BB in Indonesia A simple power function was used to represent vaccine waning over time; equivalent plots based on other potential waning functions are available in the appendix (p 19). Data points shown on the left-hand panel represent observed vaccine efficacies derived from cumulative Kaplan-Meier hazard ratios, and error bars with their corresponding 95% confidence intervals. Solid lines and dashed lines represent medians. Shaded areas represent 95% credible intervals. The Lancet Infectious Diseases 2019 19, 717-727DOI: (10.1016/S1473-3099(19)30126-4) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions