Whole animal imaging of p21 promoter activity.

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Whole animal imaging of p21 promoter activity. Whole animal imaging of p21 promoter activity. A, schematic representation of p21FLuc reporter mice with luciferase knocked into the endogenous p21 locus. B, noninvasive, whole animal imaging of p53-dependent p21 promoter activity in response to radiation in p21+/FLucTrp53+/+ and p21+/FLucTrp53fl/fl mice. C, low-light, bioluminescence microscopy of p21 promoter activity in various p21+/FLuc live tissues, including the villi from the small intestine, throughout the liver, in the epithelial cell layer below the keratinized penile spines, and in the epithelial cell layer of the vagina. Scale bars, 200 μm; 50 μm for the penis. Images from Tinkum and colleagues (37) were modified and reprinted with permission from Molecular and Cellular Biology. Brandon Kocher, and David Piwnica-Worms Cancer Discovery 2013;3:616-629 ©2013 by American Association for Cancer Research