Effect of hypothermia on cerebral blood flow and metabolism in the pig

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Presentation transcript:

Effect of hypothermia on cerebral blood flow and metabolism in the pig Marek P Ehrlich, MD, Jock N McCullough, MD, Ning Zhang, MD, Donald J Weisz, PhD, Tatu Juvonen, MD, Carol A Bodian, DrPH, Randall B Griepp, MD The Annals of Thoracic Surgery Volume 73, Issue 1, Pages 191-197 (January 2002) DOI: 10.1016/S0003-4975(01)03273-8

Fig 1 Cerebral blood flow (CBF) on cardiopulmonary bypass, measured in all 12 pigs as described in the text. Data are from Table 2. When the percentage of base line CBF is calculated for each pig at each temperature, for the two groups of pigs combined mean percentage of base line CBF (95% confidence limits) is 62% (42%, 83%) of base line at 28°C; 36% (26%, 46%) of base line at 18°C; and 43% (30%, 55%) of base line at 8°C. The Annals of Thoracic Surgery 2002 73, 191-197DOI: (10.1016/S0003-4975(01)03273-8)

Fig 2 Cerebral vascular resistance (CVR) on cardiopulmonary bypass measured in all 12 pigs as described in the text. Data are from Table 2. The Annals of Thoracic Surgery 2002 73, 191-197DOI: (10.1016/S0003-4975(01)03273-8)

Fig 3 Cerebral oxygen consumption (CMRO2) on cardiopulmonary bypass measured in all 12 pigs as described in the text. Data are from Table 3. When the percentage of base line CMRO2 is calculated for each pig at each temperature, for the two groups of pigs combined mean percentage of base line CMRO2 (95% confidence limits) is 50% (35%, 65%) of base line at 28°C; 19% (13%, 25%) of base line at 18°C; and 11% (6%, 16%) of base line at 8°C. The Annals of Thoracic Surgery 2002 73, 191-197DOI: (10.1016/S0003-4975(01)03273-8)

Fig 4 The ratio of cerebral blood flow (CBF) to cerebral oxygen consumption (CMRO2) in all 12 pigs studied. If the base line ratio is assumed to represent ideal autoregulation of cerebral blood flow to satisfy metabolic demands, then progressive loss of autoregulation is seen below 28°C and there is marked variability among animals in the degree to which autoregulation is preserved at 8°C, and often so-called luxury perfusion. The Annals of Thoracic Surgery 2002 73, 191-197DOI: (10.1016/S0003-4975(01)03273-8)

Fig 5 Data from each of the 12 pigs were used to determine the temperature coefficient (Q10) using both radioactive and fluorescent microspheres. (LN(CMRO2) = natural logarithm of oxygen consumption. Squares on solid lines = radioactive microspheres; circles on dashed lines = fluorescent microspheres.) The Annals of Thoracic Surgery 2002 73, 191-197DOI: (10.1016/S0003-4975(01)03273-8)