CEBPA gene transcriptional activation by KLF4 and p53.

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CEBPA gene transcriptional activation by KLF4 and p53. CEBPA gene transcriptional activation by KLF4 and p53. CEBPA mRNA quantitation in ME-1 AML cells induced by KLF4 and p53. A total of 10 μg plasmid DNA was nucleofected into 106 cells (A). CEBPA reporter activity in P391-HL60 cells induced by KLF4 and p53 and suppressed by AML1-ETO (B). The linearized CEBPA-BAC P391 is shown schematically. *, significant P values for t tests in subgroup versus pcDNA-transfected control. CEBPA gene HCNEs regulated luciferase reporter activity in H1299 cells induced by p53 and KLF4 (C). p53 induction of the CEBPA 36-kb 3′HCNE-driven reporter is reduced in p53 single-site and lost in p53 double-site mutation (D). KLF4 induction of the CEBPA 9-kb 3′ enhancer-driven reporter containing four putative KLF4-binding sites is reduced in the deletion constructs (D). p53 occupancy on the CEBPA 36-kb 3′ HCNE (E) and KLF4 occupancy on the CEBPA 9-kb 3′ HCNE (F) in OCI-AML3 cells treated with cytarabin/idarubicin (CI; 100 nmol/L), with the MDM2 inhibitor Nutlin-3A (Nut; 2.5 μmol/L), or with the exportin inhibitor Leptomycin-B (LMB; 2 ng/mL) for 24 hours. Katja Seipel et al. Clin Cancer Res 2016;22:746-756 ©2016 by American Association for Cancer Research