Fig. 2 From HSCT to cellular therapy.

Slides:

Advertisements

Similar presentations

CsEN components reveal precisely timed cellular programs that characterize the dynamic changes of the peripheral immune system over the course of pregnancy.

Advertisements

Fibroblast activation in WT and NFATc2-deficient mice.

Basic design concept of human mimetic humanoid.

TPAD controller performance for three force components.

Three different types of transfer functions with a codomain of [0,1].

TPAD training protocol.

Tfr cells’ transcriptomic profile distinguishes them from Treg and Tfh cells. Tfr cells’ transcriptomic profile distinguishes them from Treg and Tfh cells.

Workspace comparison of Delta robots.

Ex vivo testing of the soft robotic devices.

Fig. 1 HSCT: A platform for cellular therapies.

Soft robotic VAD implementations, control schemes, and HF models.

A novice user executing various subtasks from study 1.

Fig. 7 Correlation of NHP and human ISGs.

Soft robotic VAD implementations, control schemes, and HF models.

Fig. 1 Movement percepts for all participants.

Fig. 4. Peanut-specific TH2A cells are specifically targeted during immunotherapy. Peanut-specific TH2A cells are specifically targeted during immunotherapy.

Online verification using reachable occupancies.

Fig. 2 AcPGP induces IL-8 and G-CSF release from human bronchial epithelial cells. AcPGP induces IL-8 and G-CSF release from human bronchial epithelial.

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Fig. 7 Bacterial dependency networks in IgA deficiency and HDs.

Prosthesis system diagram.

Fig. 3 ROC curves of mCCNA1 and mVIM assayed in esophageal cytology brushings from control normal-appearing GE junctions versus BE and EAC cases. ROC curves.

Fig. 2 Preserved long-term functionality of the TEHVs over 1-year follow-up as assessed by ICE and cardiac MRI flow measurements. Preserved long-term functionality.

Inverse correlation of baseline differences between young and older participants. Inverse correlation of baseline differences between young and older participants.

Fig. 1 Map of water stress and shale plays.

Fig. 5. In vivo characterization of adipogenesis by CT.

Fig. 2 Stratigraphic profile of the Area 15 excavation block showing the diagnostic cultural materials and components alongside the stratigraphic sequence.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 4 Device accuracy results (n = 32 users).

Fig. 3 BMS blocks functional responses in primary immune cells driven by IL-23 and IL-12. BMS blocks functional responses in primary immune.

BMS blocks functional responses in primary immune cells driven by IFNα

Fig. 6 SNP rs is a functional SNP in 22Rv1 cells.

CsEN components reveal precisely timed cellular programs that characterize the dynamic changes of the peripheral immune system over the course of pregnancy.

Fig. 1 Distribution of total and fake news shares.

Fig. 2 2D QWs of different propagation lengths.

Fig. 1 From conventional cuff-based blood pressure measurement to cuff-less BP monitoring using a smartphone. From conventional cuff-based blood pressure.

AEGIS autonomous targeting process.

Fig. 3 ET dynamics on the control and treatment watersheds during the pretreatment and treatment periods. ET dynamics on the control and treatment watersheds.

Fig. 1 Histograms of the number of first messages received by men and women in each of our four cities. Histograms of the number of first messages received.

Fig. 4 Neonatal rGM-CSF corrects increased SP-D in LPL−/− mice.

Fig. 5 Schematic phase diagrams of Ising spin systems and Mott transition systems. Schematic phase diagrams of Ising spin systems and Mott transition systems.

Fig. 3 Local Maraba treatment of TNBC tumors provides long-term systemic protection. Local Maraba treatment of TNBC tumors provides long-term systemic.

Fig. 1 Average contribution (million metric tons) of seafood-producing sectors, 2009–2014. Average contribution (million metric tons) of seafood-producing.

Fig. 4 Evolution of fraction of sickled RBCs under hypoxia.

Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies by Christian Chabannon, Jurgen Kuball, Attilio Bondanza, Francesco.

Fig. 2 Schematic drawings of Göbekli Tepe skulls.

Fig. 1 Crohn’s disease association within the LRRK2 locus.

Fig. 1 Size fractions of MPPs in different fertilizers.

Fig. 2 Effect of CSF sTREM2– and CSF sTREM2–to–p-tau181 ratio on changes in cognition. Effect of CSF sTREM2– and CSF sTREM2–to–p-tau181 ratio on changes.

Fig. 5. Vascularization of human liver seed grafts.

Fig. 5 Comparison of the liquid products generated from photocatalytic CO2 reduction reactions (CO2RR) and CO reduction reactions (CORR) on two catalysts.

Schematic of the proposed brain-controlled assistive hearing device

Fig. 1 Location of the Jirzankal Cemetery.

Fig. 2 Increasing KLF17, CDH1, and LASS2 expression reduced malignant progression and promoted apoptosis of tumor cells. Increasing KLF17, CDH1, and LASS2.

Fig. 5. High burdens of AA signature mutations and predicted immunogenicity in Taiwan HCCs. High burdens of AA signature mutations and predicted immunogenicity.

Fig. 3 Characterization of SGN responses to optogenetic stimulation.

Effects of highly concentrated SFN provided as BSE in T2D patients

Fig. 1. Construction of human liver seed grafts.

Fig. 3 Comparisons of NDVI trends over the globally vegetated areas from 1982 to Comparisons of NDVI trends over the globally vegetated areas from.

Fibroblast activation in WT and NFATc2-deficient mice.

Fig. 7 BEL immune response.

Fig. 1 Schematic depiction of a paradigm for rapid and guided discovery of materials through iterative combination of ML with HiTp experimentation. Schematic.

Breakdown of incorrect participant responses.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

Fig. 3 Performance of the generative model G, with and without stack-augmented memory. Performance of the generative model G, with and without stack-augmented.

Fig. 2 Comparison between the different reflective metasurface proposals when θi = 0° and θr = 70°. Comparison between the different reflective metasurface.

Fig. 4 Gallium increases P. aeruginosa sensitivity to peroxides.

Cartoon model for the increased p-HLA display engendered by peptide splicing. Cartoon model for the increased p-HLA display engendered by peptide splicing.

Fig. 8 Immune correlates of protection.

Evaluating the performance of the robotic system through comparison with human trackers. Evaluating the performance of the robotic system through comparison.

Presentation transcript:

Fig. 2 From HSCT to cellular therapy. From HSCT to cellular therapy. Timelines summarizing the milestones in the history of HSCT that led to the development of cellular therapy and in particular to HSC gene therapy (A), to cellular therapy approaches able to promote IR after HSCT (B), and to cancer immunotherapy (C). Clinical HSCT milestones have a gray background if they are related to the donor source, and a white background and an oval shape if they are related to conditioning regimens. Milestones relating to advances in biotechnology and cellular therapy are highlighted with a black border, whereas milestones in gene therapy are highlighted with a gray border. RV, retroviral vectors; LV, lentiviral vectors; SCID-Xl, X-linked severe combined immune deficiency; CGD, chronic granulomatous disease; WAS, Wiskott-Aldrich syndrome; β-thal, β-thalassemia; MLD, metachromatic leukodystrophy; x-ALD, x-linked adrenoleukodystrophy; G-CSF, granulocyte colony-stimulating factor; UCBT, umbilical cord blood transplantation; MUD, matched unrelated donor. Christian Chabannon et al., Sci Transl Med 2018;10:eaap9630 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works