Reduction of the central nervous system adverse effects associated with antihistamines in the management of allergic disorders: Strategies and progress

Slides:

Advertisements

Similar presentations

Reducing relative humidity to control the house dust mite Dermatophagoides farinae Larry G. Arlian, PhD, Jacqueline S. Neal, BS, DiAnn L. Vyszenski-Moher,

Advertisements

Efficacy and safety profile of fexofenadine HCL

Twenty-four hour pattern in symptom intensity of viral and allergic rhinitis: Treatment implications Michael H. Smolensky, PhDa, Alain Reinberg, MDb,

Shin-Ichi Nishikawa, MD, PhD

Christine A. Sorkness, PharmD

Safety and efficacy of mometasone furoate aqueous nasal spray in children with allergic rhinitis: Results of recent clinical trials Javier Dibildox,

Use of intravenous immunoglobulin in the treatment of staphylococcal and streptococcal toxic shock syndromes and related illnesses Patrick M. Schlievert,

Laboratory animal allergy

Comparison of once-daily ebastine 20 mg, ebastine 10 mg, loratadine 10 mg, and placebo in the treatment of seasonal allergic rhinitis Paul H. Ratner,

Safety and efficacy of mometasone furoate aqueous nasal spray in children with allergic rhinitis: Results of recent clinical trials Javier Dibildox,

Practice Notes from the AAAI

Comparison of the efficacy of budesonide and fluticasone propionate aqueous nasal spray for once daily treatment of perennial allergic rhinitis James.

Efficacy and safety profile of fexofenadine HCL

Oral phenylephrine: An ineffective replacement for pseudoephedrine?

Clinical pharmacology of H1-antihistamines in the skin

Elephantiasis nostras: A case report

Adverse effects of β-agonists

The impact of allergic rhinitis on bronchial asthma

Conjunctivitis medicamentosa

The chlorofluorocarbon to hydrofluoroalkane transition: The effect on pressurized metered dose inhaler suspension stability Anne Brindley, BPharm, MRPharmS,

Side effects of inhaled corticosteroids

Anaphylactic reaction to local administration of rifamycin SV

Practice Notes from the AAAAI

Randomized, double-blind, crossover challenge study in 53 subjects reporting adverse reactions to melon (Cucumis melo) Julia Rodriguez, MDa, Jesus F.

Effect of acetazolamide on cough induced by low-chloride-ion solutions in normal subjects: Comparison with furosemide Antonio Foresi, MD, Giampaolo Cavigioli,

Increased sensitivity to bradykinin among African Americans

H.William Kelly, PharmD Journal of Allergy and Clinical Immunology

A dose-ranging study of the efficacy and safety of azelastine nasal spray in the treatment of seasonal allergic rhinitis with an acute model John M.

A review of the current guidelines for allergic rhinitis and asthma

Pathophysiology of the inflammatory response

News & Notes Journal of Allergy and Clinical Immunology

Quality of life in adults and children with allergic rhinitis

Direct exposure of carpets to sunlight can kill all mites

Effect of β-adrenergic agonists on mucociliary clearance

Nasal provocation test with lysine-aspirin for diagnosis of aspirin-sensitive asthma Mamert Milewski, MD, Lucyna Mastalerz, MD, Ewa Niżankowska, MD, Andrzej.

Montelukast adult (10-mg film-coated tablet) and pediatric (5-mg chewable tablet) dose selections Barbara Knorr, MDa, Sherry Holland, PhDb, J.Douglas.

Model for outcomes assessment of antihistamine use for seasonal allergic rhinitis Robert P. Harvey, MD, Carolyn Comer, MD, Barbara Sanders, MD, Ross Westley,

News & Notes Journal of Allergy and Clinical Immunology

Quantitation of H1-receptor antagonists in skin and serum

Prospective, long-term safety evaluation of the H1-receptor antagonist cetirizine in very young children with atopic dermatitis F.Estelle R. Simons,

Observations on emerging patterns of asthma in our society

Clinical effects of nedocromil sodium on challenges invoking neuronal mechanisms and on virally induced symptoms Peter König, MD, PhD Journal of Allergy.

The role and remediation of animal allergens in allergic diseases

Chemokines in seasonal allergic rhinitis

Exercise-induced asthma: Is it the right diagnosis in elite athletes?

Preparing patients and health professionals for the transition to chlorofluorocarbon-free inhalers: The British perspective Helen Donohoe, MSc (Econ)

Practice Notes from the AAAI

Corticosteroids in the treatment of pediatric allergic rhinitis

Use of intravenous immunoglobulin in the treatment of staphylococcal and streptococcal toxic shock syndromes and related illnesses Patrick M. Schlievert,

Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib Pär Gyllfors,

Determinants of systemic manifestations of food allergy

Robert P. Schleimer, PhD Journal of Allergy and Clinical Immunology

Abnormalities of cell and mediator levels in bronchoalveolar lavage fluid of patients with mild asthma Sally E. Wenzel, MD Journal of Allergy and Clinical.

Terence J. Furlong, MSa, Jennifer DeSimonea, Scott H. Sicherer, MDb

Further studies on the chronotherapy of asthma with inhaled steroids: The effect of dosage timing on drug efficacy Diane J. Pincus, MD, Teresa R. Humeston,

Footnotes1 Journal of Allergy and Clinical Immunology

10. Drug allergy Journal of Allergy and Clinical Immunology

Multilocalized fixed drug eruption to the antihistamine cetirizine

David P. Skoner, MD Journal of Allergy and Clinical Immunology

Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge Vernon M. Chinchilli, PhD, Laura Fisher, MD, Timothy.

Evelyn Farinas, RPh, MGA, Peter Honig, MD

The environmental predictors of allergic disease

Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal.

The preventive effect and duration of action of two doses of inhaled furosemide on exercise-induced asthma in children Elio Novembre, MD, Gianfranco.

The correlation between allergic rhinitis and sleep disturbance

News & Notes Journal of Allergy and Clinical Immunology

Antihistamine premedication in specific cluster immunotherapy: A double-blind, placebo- controlled study Lone Nielsen, MD, Claus R. Johnsen, MD, Holger.

Clinical relevance of inhaled corticosteroids and HPA axis suppression

Thomas A. E. Platts-Mills, MD, PhD, Judith A. Woodfolk, MD, Martin D

Desloratadine: A new, nonsedating, oral antihistamine

Presentation transcript:

Reduction of the central nervous system adverse effects associated with antihistamines in the management of allergic disorders: Strategies and progress Fran M. Gengo, PharmD, FCP Journal of Allergy and Clinical Immunology Volume 98, Issue 6, Pages S319-S325 (December 1996) DOI: 10.1016/S0091-6749(96)80117-5 Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 Changes in recognition time. Magnitude of peak effect produced by dimenhydrinate on reaction time is in range of that expected with BAC in 0.08 gm/100 ml (g%) range. (Reproduced with permission from Manning C, Scandale L, Manning EJ, Gengo FM. Central nervous system effects of meclizine and dimenhydrinate: evidence of acute tolerance to antihistamines. J Clin Pharmacol 1992;32:996-1002.) Journal of Allergy and Clinical Immunology 1996 98, S319-S325DOI: (10.1016/S0091-6749(96)80117-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Relative potencies of hydroxyzine (top) and cetirizine (bottom) at six receptor-binding sites in rat brain membranes. Pharmacologic specificity of hydroxyzine is such that its activity at other neurotransmitter-receptor sites is as high as its activity at histamine-receptor sites in rat brain membranes. Data for voltage sensitive calcium channels (VS Ca2+ channel) are from binding assays with [3H]nitrendipine. Ligands and assay conditions are described by Snyders and Snowman.23 5HT-2 serotonin, 5-Hydroxytryptamine-2 serotonin. (Reproduced with permission from Snyders H, Snowman AM. Receptor effects of cetirizine. Ann Allergy 1987;59(Pt II):4-8.) Journal of Allergy and Clinical Immunology 1996 98, S319-S325DOI: (10.1016/S0091-6749(96)80117-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Relative potencies of hydroxyzine (top) and cetirizine (bottom) at six receptor-binding sites in rat brain membranes. Pharmacologic specificity of hydroxyzine is such that its activity at other neurotransmitter-receptor sites is as high as its activity at histamine-receptor sites in rat brain membranes. Data for voltage sensitive calcium channels (VS Ca2+ channel) are from binding assays with [3H]nitrendipine. Ligands and assay conditions are described by Snyders and Snowman.23 5HT-2 serotonin, 5-Hydroxytryptamine-2 serotonin. (Reproduced with permission from Snyders H, Snowman AM. Receptor effects of cetirizine. Ann Allergy 1987;59(Pt II):4-8.) Journal of Allergy and Clinical Immunology 1996 98, S319-S325DOI: (10.1016/S0091-6749(96)80117-5) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 Effects of cetirizine and diphenhydramine on reaction time. In double-blind, five-way crossover study, 15 male volunteers, mean age 23.8 years, ingested placebo; cetirizine 5, 10, or 20 mg; or diphenhydramine 50 mg. Subjective measurements of drowsiness and objective measurements of mental performance were made 2 hours after dosing. During accident avoidance in automobile-driving simulation, diphenhydramine 50 mg slowed reaction time significantly compared with placebo and with cetirizine, 5, 10, or 20 mg. (Reproduced with permission from Gengo FM, Gabos C, Mechtler L. Ann Allergy 1990;64:520.) Journal of Allergy and Clinical Immunology 1996 98, S319-S325DOI: (10.1016/S0091-6749(96)80117-5) Copyright © 1996 Mosby, Inc. Terms and Conditions