A Lesson in Survival: S. aureus versus the Skin

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A Lesson in Survival: S. aureus versus the Skin Francis Alonzo, Victor J. Torres  Cell Host & Microbe  Volume 13, Issue 1, Pages 3-5 (January 2013) DOI: 10.1016/j.chom.2013.01.001 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Simplified Schematic of the Contribution of ACME to S. aureus USA300 Survival on and within Human Skin (A) Skin colonization by S. aureus is facilitated by neutralizing the acidic pH of human sweat via the production of ammonia (NH4+) from L-arginine catabolism. (B) Upon breaching the epidermal layer, a rapid inflammatory phase begins. Neutrophils and iNOS-producing macrophages are recruited to the site of infection. iNOS uses L-arginine to produce NO· to fight infection. S. aureus counters this innate immune attack via upregulation of the nitric oxide-inducible lactate dehydrogenase (ldh1). Excess L-arginine is scavenged by S. aureus, depleting arginine pools from the host and increasing L-ornithine as a by-product. (C) As infection proceeds, a postinflammatory phase begins. Expression of Arg-1 by host macrophages leads to the synthesis of polyamines, which are critical for wound healing and toxic toward most S. aureus strains. USA300 uses the ACME-encoded speG to counter polyamine toxicity. S. aureus continues to scavenge L-arginine and produces L-ornithine as a product of its catabolism. The increased L-ornithine feeds into host-derived polyamine synthesis pathways, further necessitating SpeG for S. aureus survival. Cell Host & Microbe 2013 13, 3-5DOI: (10.1016/j.chom.2013.01.001) Copyright © 2013 Elsevier Inc. Terms and Conditions