In vivo effects of TTFields on intradermal tumors in mice.

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In vivo effects of TTFields on intradermal tumors in mice. In vivo effects of TTFields on intradermal tumors in mice. Malignant melanoma (A) and adenocarcinoma (B) tumor cells were injected in two parallel locations intradermally on the back of each mouse. Only the tumor on the left side of the mouse was treated. After 4 days of TTFields treatment (at 100 kHz), no tumor can be discerned on the treated side, whereas on the untreated side a large tumor has grown. C–F, histological sections of TTFields-treated intradermal melanoma versus a control (untreated) melanoma on the same mouse. C, after H&E staining, a large (5 mm diameter) nodule of melanoma cells can be seen in the dermis of the control tumor (×40). Note that due to the large size of the tumor, its deep portion has been lost in preparation. D, treated tumor; only two small (<0.4 mm diameter) nodules are present (scale bar = 0.5 mm). The nontumor structures of the dermis are morphologically intact. E, control tumor, malignant melanoma cells appear intact and viable (×200). (Scale bar = 100 μm). F, only necrotic tissue and cellular debris are seen in the treated tumor. Eilon D. Kirson et al. Cancer Res 2004;64:3288-3295 ©2004 by American Association for Cancer Research