BMX inhibition suppresses the growth of CRPC cells in vitro and in vivo. BMX inhibition suppresses the growth of CRPC cells in vitro and in vivo. A, CWR22RV1.

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BMX inhibition suppresses the growth of CRPC cells in vitro and in vivo. BMX inhibition suppresses the growth of CRPC cells in vitro and in vivo. A, CWR22RV1 cells were treated with BMX-IN-1 (Bi1) or BMX-IN-1R (BilR) as a negative control for 72 hours and then measured for viability (mean ± SE, n = 4). B, CWR22RV1 cells were treated with ibrutinib for 72 hours and then measured for viability (mean ± SE, n = 4). CWR22RV1 cells were cultured in Matrigel-based 3D system with indicated BMX-IN-1 or control treatment for 2 to 3 weeks (C) and analyzed for colony number (left) and average diameters (right; mean ± SE; n = 5 for left plot and n = 10 for right plot; D). E, CWR22RV1 cells were cultured in Matrigel-based 3D system with ibrutinib or control treatment for 2 weeks, and colonies were analyzed for numbers and average diameters (mean ± SE; n = 8 for left plot and n = 20 for right plot). F, CWR22RV1 xenograft–bearing mice were administered 0, 50, or 100 mg/kg/d of BMX-IN-1 (Bi1), and growth was monitored (mean ± SE; n = 9 for vehicle, n = 5 for 100 mg/kg/d, and n = 6 for 50 mg/kg/d). G, CWR22RV1 xenograft–bearing mice were administered 0 or 150 mg/kg/d of ibrutinib, and tumor growth was monitored (mean ± SE; n = 9 for vehicle, n = 5 for 150 mg/kg/d of ibrutinib). H, DU145 xenograft–bearing mice were administered with 0 or 100 mg/kg/d of BMX-IN-1 (Bi1), and growth was monitored (mean ± SE; n = 5). *, P < 0.05; **, P < 0.01; ***, P < 0.001. Sen Chen et al. Cancer Res 2018;78:5203-5215 ©2018 by American Association for Cancer Research