Baseline and 1-month data for the abstinence group presented as pre/post scatter plot (left) and bar chart chart (right). Bar chart data are presented as median (IQR). Baseline and 1-month data for the abstinence group presented as pre/post scatter plot (left) and bar chart chart (right). Bar chart data are presented as median (IQR). Panels (clockwise from top right): homeostatic model assessment (HOMA) score, weight, diastolic blood pressure (bp), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), systolic bp. Baseline and 1-month values were compared with Wilcoxon signed-rank test, p<0.01 taken as level of significance. Gautam Mehta et al. BMJ Open 2018;8:e020673 ©2018 by British Medical Journal Publishing Group