Fig. 2 Increasing KLF17, CDH1, and LASS2 expression reduced malignant progression and promoted apoptosis of tumor cells. Increasing KLF17, CDH1, and LASS2.

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Fig. 2 Increasing KLF17, CDH1, and LASS2 expression reduced malignant progression and promoted apoptosis of tumor cells. Increasing KLF17, CDH1, and LASS2 expression reduced malignant progression and promoted apoptosis of tumor cells. (A) Western blot analysis of KLF17, CDH1, and LASS2 expression in HeLa cells transfected with pcDNA3.1-KLF17, pcDNA3.1-CDH1, or pcDNA3.1-LASS2, respectively. (B) Cell proliferation, (C) migration (scale bars, 50 μm), (D) invasion (scale bars, 100 μm), (E) colony formation (scale bars, 2 mm), and (F) apoptosis of HeLa cells transfected with pcDNA3.1-KLF17, pcDNA3.1-CDH1, and pcDNA3.1-LASS2 were measured. FITC, fluorescein isothiocyanate. All data are represented as means ± SEM versus control group. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Jing Meng et al., Sci Transl Med 2018;10:eaao6321 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works