Reproductive BioMedicine Online

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Reproductive BioMedicine Online Controversies in ART: can the IVF laboratory influence preimplantation embryo aneuploidy?  Jason E. Swain  Reproductive BioMedicine Online  DOI: 10.1016/j.rbmo.2019.06.009 Copyright © 2019 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Common stressors within the culture system that impact embryo development in vitro and may potentially impact machinery responsible for proper mitotic cell division and separation/segregation of chromosomes. While each stressor alone may not cause a significant increase in aneuploidy, subtle stress from multiple sources may yield a cumulative effect that could explain wide variations in embryo aneuploidy between laboratories reported in the literature. Reproductive BioMedicine Online DOI: (10.1016/j.rbmo.2019.06.009) Copyright © 2019 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Increasing media osmolality disrupts the human oocyte meiotic spindle. For every 1 mOsm increase, the spindle is disrupted by an odds ratio of 1.001–1.004 (adapted from Mullen et al., 2004). Reproductive BioMedicine Online DOI: (10.1016/j.rbmo.2019.06.009) Copyright © 2019 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 Impact of a temperature gradient on mouse embryo morphokinetic (mitotic division) timings and blastocyst development (Walters et al., 2018). Different superscripts within a stage represent statistically significant differences, P < 0.05. Reproductive BioMedicine Online DOI: (10.1016/j.rbmo.2019.06.009) Copyright © 2019 Reproductive Healthcare Ltd. Terms and Conditions

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