Table S1. Diet formulation*

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Table S1. Diet formulation* Ingredient (g) AIN-93G Diet 1 (0 g of sucrose) Diet 2 (125 g of sucrose) Diet 3 (250 g of sucrose) Diet 4 (500 g of sucrose) Casein 200 230 L-Cystine 3 Corn Starch 400 500 375 250 Maltodextrin 10 132 100 Sucrose 125 Cellulose, BW200 50 Soybean Oil 70 T-Butylhydroquinone 0.014 Mineral Mix 35 Vitamin Mix 10 Choline Bitartrate 2.5 Total 1000 *a. diets used in MMVT/neu mouse model; b. diets used in MDA-MB-231 or 4T1 cell bearing mice; c. diets used in 4T1 cell bearing mice for the sucrose, glucose and fructose study

b. Ingredient (g) AIN-93G Diet 1 (0 g of sucrose) Casein 200 L-Cystine 3 Corn Starch 400 500 437.5 375 250 Maltodextrin 10 132 Sucrose 100 62.5 125 Cellulose, BW200 50 Soybean Oil 70 T-Butylhydroquinone 0.014 Mineral Mix 35 Vitamin Mix 10 Choline Bitartrate 2.5 Total 1000

c. Ingredient (g) AIN-93G Diet 1 (0 g of sucrose) Diet 3 (125 g of glucose) Diet 4 (125 g of fructose) Diet 5 (125 g of glucose + 125 g of fructose) Casein 200 L-Cystine 3 Corn Starch 400 500 250 375 Maltodextrin 10 132 Sucrose 100 Dextrose 125 Fructose Cellulose, BW200 50 Soybean Oil 70 T-Butylhydroquinone 0.014 Mineral Mix 35 Vitamin Mix 10 Choline Bitartrate 2.5 Total 1000