A, DMA and Ral significantly inhibit estrone methyl ether (MeOE1) formation in MCF-10A cells. A, DMA and Ral significantly inhibit estrone methyl ether.

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A, DMA and Ral significantly inhibit estrone methyl ether (MeOE1) formation in MCF-10A cells. A, DMA and Ral significantly inhibit estrone methyl ether (MeOE1) formation in MCF-10A cells. MCF-10A cells were treated for 6 days with E2 (1 μmol/L) in the presence and absence of SERMs (1 μmol/L). Cell media were analyzed for 2-MeOE1 and 4-MeOE1 formation using LC/MS-MS and an internal standard. “% MeOE1” was normalized to 100% representing cells treated with E2 alone. Attenuation of 4-MeOE1 formation with DMA or Ral cotreatment was significant; FDMA had no effect. Each data point represents an average of 3 independent experiments ± SD. *, P < 0.05. DMA (B) and Ral (C) showed a dose-dependent inhibition in both 4-MeOE1 and 2-MeOE1 formation in MCF-10A cells. Each data point represents an average of 3 independent experiments ± SD. D, modulation of MeOE1 formation by Baze or 4-OHTam cotreatment. Each data point represents an average of 3 independent experiments ± SD. *, P < 0.05. L.P. Madhubhani P. Hemachandra et al. Cancer Prev Res 2014;7:505-515 ©2014 by American Association for Cancer Research