Aspirin therapy inhibits NLRP1 (nucleotide-binding domain-like receptor protein 1) inflammasome gene expression in patients with peripheral artery disease

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Presentation transcript:

Aspirin therapy inhibits NLRP1 (nucleotide-binding domain-like receptor protein 1) inflammasome gene expression in patients with peripheral artery disease Silvia Bleda, MD, Joaquin De Haro, MD, Cesar Varela, MD Journal of Vascular Surgery Volume 61, Issue 4, Pages 1103-1104 (April 2015) DOI: 10.1016/j.jvs.2014.12.056 Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig Human aortic endothelial cells (HAECs) exposed to plasma of 63 patients with peripheral arterial disease (PAD) with aspirin treatment show lower expression of NLRP1 (nucleotide-binding oligomerization domain receptors family, pyrin domain containing 1) inflammasome compared with HAECs exposed to plasma of 50 PAD patients without aspirin treatment. *P = .04. NLRP1 gene expression levels are given as mean ± standard deviation. RQ, Relative quantification. Journal of Vascular Surgery 2015 61, 1103-1104DOI: (10.1016/j.jvs.2014.12.056) Copyright © 2015 Society for Vascular Surgery Terms and Conditions