Ibrutinib Treatment of CLL: The Cancer Fights Back

Slides:

Advertisements

Similar presentations

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals Xiang H.-F. Zhang, Qiongqing Wang, William Gerald, Clifford A. Hudis, Larry.

Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Genome-wide Single-Cell Analysis of Recombination Activity and De Novo Mutation Rates in Human Sperm Jianbin Wang, H. Christina Fan, Barry Behr, Stephen.

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells Nilay Sethi, Xudong Dai, Christopher.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Targeting Androgen Receptor in Estrogen Receptor-Negative Breast Cancer Min Ni, Yiwen Chen, Elgene Lim, Hallie Wimberly, Shannon T. Bailey, Yuuki Imai,

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.

Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma Laurence Lamy, Vu N. Ngo, N.C. Tolga Emre, Arthur L. Shaffer, Yandan Yang, Erming Tian,

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung Zvi Granot, Erik Henke, Elizabeth A. Comen, Tari A. King, Larry Norton, Robert Benezra.

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

A Conditional Mouse Model for Malignant Mesothelioma Johan Jongsma, Erwin van Montfort, Marc Vooijs, John Zevenhoven, Paul Krimpenfort, Martin van der.

A Conditional Mouse Model of Synovial Sarcoma: Insights into a Myogenic Origin Malay Haldar, Jeffrey D. Hancock, Cheryl M. Coffin, Stephen L. Lessnick,

Par-4 Downregulation Promotes Breast Cancer Recurrence by Preventing Multinucleation following Targeted Therapy James V. Alvarez, Tien-chi Pan, Jason Ruth,

PI3Kδ Inhibition Hits a Sensitive Spot in B Cell Malignancies

Charles Swanton, Julian Downward Cancer Cell

Building better therapy for children with acute lymphoblastic leukemia

“Atypical” Regulation of Hedgehog-Dependent Cancers

Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension

The Metastasis Problem Gets Stickier

Accelerating drug discovery: Open source cancer cell biology?

Christian Grommes, Anas Younes Cancer Cell

Volume 9, Issue 6, Pages (June 2006)

Volume 14, Issue 2, Pages (August 2008)

Volume 11, Issue 4, Pages (April 2007)

A Mitochondrial Power Play in Lymphoma

A Jagged Road to Lymphoma Aggressiveness

RAS’s Cloak of Invincibility Slips at Last?

Cell signaling and cancer

MDS Is a Stem Cell Disorder After All

DAISY: Picking Synthetic Lethals from Cancer Genomes

Deregulating EMT and Senescence: Double Impact by a Single Twist

Volume 26, Issue 1, Pages 1-2 (July 2014)

T.S. Karin Eisinger-Mathason, M. Celeste Simon Cancer Cell

A Radical Role for p38 MAPK in Tumor Initiation

Volume 9, Issue 6, Pages (June 2006)

CALming Down T Cell Acute Leukemia

Coordinate Transcriptional Regulation by ERG and Androgen Receptor in Fusion- Positive Prostate Cancers Yu Chen, Charles L. Sawyers Cancer Cell Volume.

Hopping between Differentiation States in Lung Adenocarcinoma

Volume 46, Issue 5, Pages (June 2012)

Volume 20, Issue 1, Pages 3-5 (July 2011)

Targeting β-catenin in CML: Leukemia Stem Cells Beware!

A New “Brew” of MALT1 Inhibitors

Deregulating EMT and Senescence: Double Impact by a Single Twist

Lung Cancer: A Wily Genetic Opponent

The RAF Inhibitor Paradox Revisited

RalGDS comes of age Cancer Cell

Andrew J. Holland, Don W. Cleveland Cancer Cell

PI3Kδ Inhibition Hits a Sensitive Spot in B Cell Malignancies

NOTCH and PI3K-AKT Pathways Intertwined

Dolors Colomer, Elías Campo Cancer Cell

John D. Gordan, Craig B. Thompson, M. Celeste Simon Cancer Cell

Volume 22, Issue 2, Pages (August 2012)

William G. Nelson, Michael C. Haffner, Srinivasan Yegnasubramanian

Volume 14, Issue 4, Pages (October 2008)

To Infinium, and Beyond! Cancer Cell

Volume 10, Issue 3, Pages (September 2006)

All Roads Lead to the Ribosome

Radiation resistance and stem-like cells in brain tumors

Attacking Cancer at Its Root

Searching for leukemia stem cells—Not yet the end of the road?

Volume 12, Issue 6, Pages (December 2007)

The Role of TET2 in Hematologic Neoplasms

Presentation transcript:

Ibrutinib Treatment of CLL: The Cancer Fights Back Ryan M. Young, Louis M. Staudt Cancer Cell Volume 26, Issue 1, Pages 11-13 (July 2014) DOI: 10.1016/j.ccr.2014.06.023 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 B Cell Receptor Signaling in Malignant B Cells Chronic active BCR signaling is shown. Ibrutinib is shown to inhibit BTK. Red asterisks denote signaling effectors that are the target of ibrutinib resistance mutations in CLL patients. Cancer Cell 2014 26, 11-13DOI: (10.1016/j.ccr.2014.06.023) Copyright © 2014 Elsevier Inc. Terms and Conditions