A randomized, triple-masked, active-controlled investigation of the relative effects of dose, concentration, and infusion rate for continuous popliteal-sciatic.

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Presentation transcript:

A randomized, triple-masked, active-controlled investigation of the relative effects of dose, concentration, and infusion rate for continuous popliteal-sciatic nerve blocks in volunteers S.J. Madison, A.M. Monahan, R.R. Agarwal, T.J. Furnish, E.J. Mascha, Z. Xu, M.C. Donohue, A.C. Morgan, B.M. Ilfeld British Journal of Anaesthesia Volume 114, Issue 1, Pages 121-129 (January 2015) DOI: 10.1093/bja/aeu333 Copyright © 2015 The Author(s) Terms and Conditions

Fig 1 Consolidated Standards of Reporting Trials (CONSORT) flow diagram. British Journal of Anaesthesia 2015 114, 121-129DOI: (10.1093/bja/aeu333) Copyright © 2015 The Author(s) Terms and Conditions

Fig 2 Effects of continuous popliteal-sciatic nerve block ropivacaine concentration/volume combination on tolerance to cutaneous electrical current within the sciatic nerve distribution. Data are expressed as mean (solid circle) with standard error (whiskers) for limbs randomly assigned to receive ropivacaine 0.1% (basal 8 ml h−1=8 mg h−1) or 0.4% (basal 2 ml h−1=8 mg h−1). When assessed at individual time points, equivalence was concluded at all time points using raw P-values, and at most time points when adjusting for multiple comparisons (Table 2). Since the time-by-treatment interaction was not statistically significant (P>0.99), equivalence in the treatment effect was assessed marginally by collapsing over time: the mean difference (0.1−0.4%) was 0.2 (90% CI: −2.3 to 2.8) mA, which was well contained within the a priori equivalence region of −10 to 10 mA (P<0.001). British Journal of Anaesthesia 2015 114, 121-129DOI: (10.1093/bja/aeu333) Copyright © 2015 The Author(s) Terms and Conditions

Fig 3 Effects of continuous popliteal-sciatic nerve block ropivacaine concentration/volume combination on MVIC during plantar flexion. Data are expressed as mean (solid circle) with standard error (whiskers) for limbs randomly assigned to receive ropivacaine 0.1% (basal 8 ml h−1=8 mg h−1) or 0.4% (basal 2 ml h−1=8 mg h−1). When assessed at individual time points, equivalence was concluded at most time points using raw P-values, but at only a few time points when adjusting for multiple comparisons (Table 3). Since the time-by-treatment interaction was not statistically significant (P=0.98), equivalence in the treatment effect was assessed marginally by collapsing over time: the mean difference (0.1−0.4%) was 0.7 (90% CI: −4.1 to 5.6)%, which was well contained within the a priori equivalence region of −20 to 20% of baseline (P<0.001). British Journal of Anaesthesia 2015 114, 121-129DOI: (10.1093/bja/aeu333) Copyright © 2015 The Author(s) Terms and Conditions