Effect of MZ treatment on lung colony formation in an experimental metastasis. Effect of MZ treatment on lung colony formation in an experimental metastasis.

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Effect of MZ treatment on lung colony formation in an experimental metastasis. Effect of MZ treatment on lung colony formation in an experimental metastasis. A, A549 cells formed colonies on lung surfaces when injected through the tail vein. C, control mouse received no treatment; T, MZ-treated mice received 1 mg of MZ p.o. twice a week for 3 weeks. The white spots on the lung surfaces (arrows) are colonies. B, quantitation of lung colonies in control and MZ-treated animals (P < 0.0001); the total number of lung colonies/animal were plotted. C, H&E-stained lung sections show the sizes of tumor colonies in control (Con) and MZ-treated (MZ) animals. The colonies are indicated by dotted lines. Tapas Mukhopadhyay et al. Clin Cancer Res 2002;8:2963-2969 ©2002 by American Association for Cancer Research