Identity Crisis: It’s Not Just Foxp3 Anymore

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Presentation transcript:

Identity Crisis: It’s Not Just Foxp3 Anymore Greg M. Delgoffe, Matthew L. Bettini, Dario A.A. Vignali Immunity Volume 37, Issue 5, Pages 759-761 (November 2012) DOI: 10.1016/j.immuni.2012.10.012 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 TCR-Induced CpG Hypomethylation of Treg Cell Signature Genes Facilitates Treg Cell Development and Stability Treg cells lacking nTreg-Me (methylation is depicted with white triangles) are more plastic and display decreased suppressive function and potential loss of Foxp3 expression. Strong TCR signals in the thymus or continuous TCR signals in the periphery can induce nTreg-Me in several Treg cell signature genes, although there might be additional signals that further influence the development of the nTreg-Me phenotype in T cells. Immunity 2012 37, 759-761DOI: (10.1016/j.immuni.2012.10.012) Copyright © 2012 Elsevier Inc. Terms and Conditions