Low/moderate intensity statins High intensity statins

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Low/moderate intensity statins High intensity statins In PAD, statin therapy was associated with a significant reduction of amputations and mortality compared with no statin use Outcome Low/moderate intensity statins High intensity statins Mortality HRadj: 0.83; 95%CI: 0.81-0.86 HRadj: 0.74; 95%CI: 0.70-0.77 Amputations HRadj: 0.81; 95%CI: 0.75-0.86 HRadj: 0.67; 95%CI: 0.61-0.74 PAD: peripheral artery disease; Adjusted for age, PAD diagnosis year, race, gender, socio-economic status, body mass index, comorbidities, including diabetes, hypertension, heart failure, chronic obstructive pulmonary disease, atrial fibrillation, carotid disease, depression, chronic kidney disease and end stage renal disease, antiplatelet medications, cilostazol, PAD severity, and serum creatinine Arya et al. Circulation 2018