Prospective randomized double-blind trial of the correlation between time of administration and antiestrogenic effects of clomiphene citrate on reproductive.

Slides:



Advertisements
Similar presentations
Low-dose aspirin in non-tubal IVF patients with previous failed conception: a prospective randomized double-blind placebo-controlled trial  Marieke J.
Advertisements

Male contraception Fertility and Sterility
Follicular and endocrine response to anastrozole versus clomiphene citrate administered in follicular phase to normoovulatory women: a randomized comparison 
The normal variabilities of the menstrual cycle
A prospective, randomized, double-blinded study of assisted hatching in women younger than 38 years undergoing in vitro fertilization  Andrea R. Hagemann,
What is the optimal follicular size before triggering ovulation in intrauterine insemination cycles with clomiphene citrate or letrozole? An analysis.
Growth rates of ovarian follicles during natural menstrual cycles, oral contraception cycles, and ovarian stimulation cycles  Angela R. Baerwald, Ph.D.,
Comparison of fallopian tube sperm perfusion and intrauterine tuboperitoneal insemination: a prospective randomized study  Leonidas Mamas, M.D., Ph.D. 
A randomized controlled study comparing the endocrine effects of pulsatile intravenous gonadotropin-releasing hormone after gonadotropin-releasing hormone.
A prospective randomized controlled trial of preimplantation genetic screening in the “good prognosis” patient  Liza R. Meyer, M.S., Sigal Klipstein,
Serum antimüllerian hormone levels remain stable throughout the menstrual cycle and after oral or vaginal administration of synthetic sex steroids  Isabelle.
Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature.
Effects of letrozole and clomiphene citrate on the expression of HOXA10 and integrin αvβ3 in uterine epithelium of rats  Shi Hua Bao, M.D., Ph.D., Shi.
Follicle-stimulating hormone administered at the time of human chorionic gonadotropin trigger improves oocyte developmental competence in in vitro fertilization.
Evaluation of an ultra-low-dose oral contraceptive for dysmenorrhea: a placebo- controlled, double-blind, randomized trial  Tasuku Harada, M.D., Mikio.
Kimberly Elford, M.D., Paul Claman, M.D.  Fertility and Sterility 
Grant D.E. McWilliams, D.O., John L. Frattarelli, M.D. 
Zeev Shoham, M.D.  Fertility and Sterility 
Randomized, controlled pilot trial of natural versus hormone replacement therapy cycles in frozen embryo replacement in vitro fertilization  Ginny Mounce,
Surgical treatment of endometriosis: a prospective randomized double-blinded trial comparing excision and ablation  Martin Healey, M.D., W. Catarina Ang,
Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized.
Does endometrial integrin expression in endometriosis patients predict enhanced in vitro fertilization cycle outcomes after prolonged GnRH agonist therapy? 
Angela R. Baerwald, Ph. D. , Olufemi A. Olatunbosun, M. D. , Roger A
Robert F. Casper, M.D.  Fertility and Sterility 
A prospective randomized clinical trial of differing starter doses of recombinant follicle- stimulating hormone (follitropin-β) for first time in vitro.
Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium  Akihisa Takasaki,
Impact of luteal phase support on pregnancy rates in intrauterine insemination cycles: a prospective randomized study  Ahmet Erdem, M.D., Mehmet Erdem,
Anastrozole vs. clomiphene citrate in infertile women with ovulatory dysfunction: a phase II, randomized, dose-finding study  Donald Tredway, M.D., Ph.D.,
Conversion of high-response gonadotropin intrauterine insemination cycles to in vitro fertilization results in excellent ongoing pregnancy rates  Amy.
Evaluation of the relationship between plasma concentrations of en- and zuclomiphene and induction of ovulation in anovulatory women being treated with.
Benny Almog, M. D. , Fady Shehata, M. B. , B. Ch. , M. Sc
A randomized clinical trial of endometrial perfusion with granulocyte colony-stimulating factor in in vitro fertilization cycles: impact on endometrial.
Endometrial wavelike activity, endometrial thickness, and ultrasound texture in controlled ovarian hyperstimulation cycles  Marga M IJland, M.D., Johannes.
Tomer Singer, M. D. , David H. Barad, M. D. , M. S
Robotic-assisted laparoscopic ovarian tissue transplantation
Clomiphene citrate at 50: the dawning of assisted reproduction
Synchronization of ovarian stimulation with follicle wave emergence in patients undergoing in vitro fertilization with a prior suboptimal response: a.
Effects of laparoscopic ovarian drilling on serum vascular endothelial growth factor and on insulin responses to the oral glucose tolerance test in women.
Ri-Cheng Chian, Ph. D. , Jack Y. J. Huang, M. D. , Lucy Gilbert, M. D
Vaginally administered estroprogestinic decreases serum inhibin A and inhibin B levels and reduces endometrial thickness  Stefano Luisi, M.D., Lavinia.
Immature oocyte retrieval and in vitro oocyte maturation at different phases of the menstrual cycle in women with cancer who require urgent gonadotoxic.
Effect of letrozole at 2. 5 mg or 5
Concentrations of inhibins and activin in women undergoing stimulation with recombinant follicle-stimulating hormone for in vitro fertilization treatment 
Mean versus individual hormonal profiles in the menstrual cycle
CDB-2914, a novel selective progesterone receptor modulator, differentially regulates endometrial gene expression in the proliferative phase of the menstrual.
Prospective cohort study of three- versus two-dimensional ultrasound for prediction of oocyte maturity  Doron Shmorgun, M.D., Edward Hughes, M.D., Patrick.
Difference between serum beta-human chorionic gonadotropin levels in pregnancies after in vitro maturation and in vitro fertilization treatments  Benny.
Predictive usefulness of cycle day 10 follicle-stimulating hormone level in a clomiphene citrate challenge test for in vitro fertilization outcome in.
Comparison of basal follicle-stimulating hormone versus the clomiphene citrate challenge test for ovarian reserve screening  Tarun Jain, M.D., Michael.
A double-blind clinical trial comparing a fixed daily dose of 150 and 250 IU of recombinant follicle-stimulating hormone in women undergoing in vitro.
Regulation of assisted reproductive technologies in the United States
Simvastatin improves biochemical parameters in women with polycystic ovary syndrome: results of a prospective, randomized trial  Antoni J. Duleba, M.D.,
Fertility and Sterility and impact factor
Decreased levels of interleukin-18 in peritoneal fluid but not in serum of patients with endometriosis  Xinmei Zhang, M.D., Jun Lin, M.D., Yuli Qian,
Effects of metformin on body mass index, menstrual cyclicity, and ovulation induction in women with polycystic ovary syndrome  Derek A Haas, M.D., Bruce.
Moderately elevated levels of basal follicle-stimulating hormone in young patients predict low ovarian response, but should not be used to disqualify.
Effectiveness of cetrorelix for the prevention of premature luteinizing hormone surge during controlled ovarian stimulation using letrozole and gonadotropins:
Fertility and Sterility
Thin endometrial stripe does not affect likelihood of achieving pregnancy in clomiphene citrate/intrauterine insemination cycles  Albert Asante, M.D.,
Ronald M. Yang, M. D. , Richard A. Fefferman, M. D. , Charles E
Defining the proliferative phase endometrial defect
In vitro sildenafil citrate use as a sperm motility stimulant
Early follicular serum müllerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles  David.
Anastrozole single-dose protocol in women with oligo- or anovulatory infertility: results of a randomized phase II dose–response study  Donald Tredway,
Progesterone level and progesterone/estradiol ratio on the day of hCG administration: detrimental cutoff levels and new treatment strategy  Eman A. Elgindy,
The treatment of hypogonadism in men of reproductive age
Conversion from assisted reproductive technology to intrauterine insemination in low responders: Is it advantageous?  John M. Norian, M.D., Eric D. Levens,
Randomized, controlled pilot trial of natural versus hormone replacement therapy cycles in frozen embryo replacement in vitro fertilization  Ginny Mounce,
Endometrial polyps affect uterine receptivity
Basal antral follicle number and mean ovarian diameter predict cycle cancellation and ovarian responsiveness in assisted reproductive technology cycles2 
Presentation transcript:

Prospective randomized double-blind trial of the correlation between time of administration and antiestrogenic effects of clomiphene citrate on reproductive end organs  Marinko M Biljan, Neal G Mahutte, M.D., Togas Tulandi, M.D., Seang Lin Tan  Fertility and Sterility  Volume 71, Issue 4, Pages 633-638 (April 1999) DOI: 10.1016/S0015-0282(98)00534-2

FIGURE 1 Mean (SE) of (A) FSH, (B) LH, (C) E2 levels, and (D) number of follicles >14 mm between the patients in the study group who had CC administered on days 1–5 of the menstrual cycle (-○-) and the patients in the control group who had CC administered on days 5–9 of the menstrual cycle (-■-). P values represent the differences between the two studied groups on the same day of the menstrual cycle. Fertility and Sterility 1999 71, 633-638DOI: (10.1016/S0015-0282(98)00534-2)

FIGURE 2 The changes in endometrial thickness (A) and pulsatility index (B) expressed as mean (SE) between the patients in the study group who had CC administered on days 1–5 of the menstrual cycle (-○-) and the patients in the control group who had CC administered on days 5–9 of the menstrual cycle (-■-). P values represent the differences between the two studied groups on the same day of the menstrual cycle. Fertility and Sterility 1999 71, 633-638DOI: (10.1016/S0015-0282(98)00534-2)