A Long-Distance Relay-tionship between Tumor and Bone Klara Soukup, Johanna A. Joyce  Immunity  Volume 48, Issue 1, Pages 13-16 (January 2018) DOI: 10.1016/j.immuni.2017.12.011 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Lung Tumors Can Engage Distant Osteoblasts to Drive Pro-tumoral Granulopoiesis Through the systemic release of the soluble receptor for advanced glycation end products (sRAGE), lung tumors signal to remote bone-resident osteoblasts (in blue). This signal leads to osteoblast activation, which in turn promotes the generation of a specific subset of tumorigenic neutrophils. Sialic acid-binding immunoglobulin-like lectin F high-expressing (SiglecFhi) neutrophils (in green) are thereby mobilized in circulation to the primary tumor site, where they can promote cancer progression. SiglecFhi neutrophils gradually obtain their tumor-promoting phenotype as they travel toward the tumor tissue, where their education into potent tumor-enhancing cells can be completed (shaded green of increased intensity). Immunity 2018 48, 13-16DOI: (10.1016/j.immuni.2017.12.011) Copyright © 2017 Elsevier Inc. Terms and Conditions