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Supplementary Material Suppl. Fig. S1 HSF-1 knockdown cells show no difference in cell cycle distribution after combined Hsp90 inhibition and irradiation H1339 ctrl and HSF-1 k.d. cells were treated with 10nM NVP-AUY922 for 24h and irradiated with 6Gy. Cells were stained with PI to analyse cell cycle distribution 24h after irradiation.

Supplementary Material Suppl. Fig. S2 HSF-1 knockdown and control cells show no difference in apoptosis induction after combined Hsp90 inhibition and irradiation A. Measurement of apoptosis induction 24h after irradiation by Annexin V and B. Caspase-3 staining of H1339 ctrl and HSF-1 k.d. cells treated with 10nM NVP-AUY922 for 24h following irradiation with 6Gy.

Supplementary Material Supplementary Table S1: Summary of radiobiological parameters A. Loss of HSF-1 per se has no influence on radiosensitivity. D50, dose to reduce survival fraction to 50%. Sensitizing enhancement ratio (SER) = D50(irradiation ctrl)/D50(irradiation HSF-1 k.d.). B. Radiosensitizing effect of Hsp90 inhibition is much more pronounced in H1339 HSF-1 k.d. cells compared to control cells. SER ( D50(irradiation)/D50(irradiation + drug)) greater than 1.20 is indicative for radiosensitization (indicated in bold).