Serial determinations of both anti-chromatin and anti-dsDNA antibodies in a patient who developed lupus nephropathy during the study period, showing that anti-chromatin antibodies appeared before anti-dsDNA antibodies. Serial determinations of both anti-chromatin and anti-dsDNA antibodies in a patient who developed lupus nephropathy during the study period, showing that anti-chromatin antibodies appeared before anti-dsDNA antibodies. R Cervera et al. Ann Rheum Dis 2003;62:431-434 ©2003 by BMJ Publishing Group Ltd and European League Against Rheumatism